CONTACT:

School of Pharmaceutical and Life Sciences

Changzhou University （常州大學(xué)制藥與生命科學(xué)學(xué)院）

Changzhou, Jiangsu 213164, China

Cell: 15861150838

Email Address： huadongxu@gmail.com

xuhd@cczu.edu.cn

RESEARCH INTERESTS:

Organic methodology research by Organometallic Chemistry and Sugar Chemistry.

(有機(jī)方法學(xué)研究，重點(diǎn)運(yùn)用金屬有機(jī)化學(xué)方法和糖化學(xué)方法)

Drug research and development for treating cancers.

(新型抗癌藥物的研究)

FUNDINGS:

2013國(guó)家自然科學(xué)基金面上項(xiàng)目（項(xiàng)目批準(zhǔn)號(hào)：21272077）

2011國(guó)家自然科學(xué)青年基金（項(xiàng)目批準(zhǔn)號(hào)：21002032）

2011浦江人才基金 （11PJ1403100）

PROFESSIONAL EXPERIENCE:

2012-presentProfessor

School of Pharmaceutical and Life Sciences, Changzhou University, China.

2010-2012Associate Professor

East China Normal University, Shanghai. (華東師范大學(xué))

2009-2010Senior Research Scientist

PharmaResources Shanghai CO. LTD.(上海鴻博智源醫(yī)藥研究有限公司)

2007-2009Postdoctoral Research Associate

Chemistry Department, University of Wisconsin-Madison, USA. (威斯康星大學(xué)-麥迪遜分校)

2003-2007Teaching Assistant and Research Assistant

Chemistry Department, University of Illinois at Chicago, USA．(伊利諾依大學(xué)-芝加哥分校)

2000-2003Assistant Researcher

Daiwei Ma’ s Research Group, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所)

EDUCATIONAL BACKGROUND:

2007Ph.D in Organic Chemitry, Chemistry Department, University of Illinois at Chicago, USA. (伊利諾依大學(xué)-芝加哥分校)

2000 Master in Organic Chemistry, East China University of Science and Technology (Shanghai, P. R. China) （華東理工大學(xué)）

1998 Bachelor in Chemistry, Lanzhou University ( 蘭州大學(xué))

SELECTED PUBLICATIONS:

1．Synthesis of β-diazo-α-ketoamide and their cyclopropanation reaction with alkenes. Chen, X.; Hu, W.; Li, X.*; Xu, H-D.*Chin. J. Syn. Chem. 2012, 20, 1.

2．3-Diazo-N-[(2S)-1-hydroxypropan-2-yl]-2-oxopropanamide. Chen, X.; Hu, W.; Li, X.*; Xu, H-D.* Acta Cryst. 2011, E67, o1192.

3．Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, Jiang, J.; Xu, H-D.; Xi, J.; Hu, W.* J. Am. Chem. Soc. 2011, 133, 8428.

4．Thermodynamic Control of the Electrocyclic Ring Opening of Cyclobutenes: C=X Substituents at C-3 Mask the Kinetic Torquoselectivity Um, J. M.; Xu, H-D.; Houk, K. N. *; Tang, W. * J. Am. Chem. Soc. 2009, 131, 6664.

5．DABCO-Catalyzed 1,4-Bromolactonization of Conjugated Enynes: Highly Stereoselective Formation of a Stereogenic Center and an Axially Chiral Allene, Zhang, W.; Xu, H-D.; Tang, W. * J. Am. Chem. Soc. 2009, 131, 3832.

6．Highly Selective Synthesis of Cyclobutenes via Transition Metal Catalyzed Rearrangement of Cyclopropyl Metal Carbenes. Xu, H-D., Zhang, W., Shu, D., Werness, J. B. and Tang, W. * Angew. Chem. 2008,47,8933.

7．Direct stereocontrolled synthesis of 3-amino-3-deoxy-β-mannopyranosides: importance of the nitrogen protecting group on stereoselectivity. Crich, D. *; Xu, H-D. J. Org. Chem. 2007, 72, 5183

8．Total synthesis and structural verification of some novel branched alkanes with quaternary carbons isolated from diverse geological sources. Crich, D. *; Xu, H-D.; Kenig, F. J. Org. Chem. 2006, 71, 5016.

9．Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline ligands for Ru-catalyzed asymmetric transfer hydrogenation of ketones. Zhou, Y.; Tang, F.; Xu, H-D.; Wu, X.; Ma, J.; Zhou Q. * Tetrahedron: Asymmetry 2002, 13, 469.

10．Remote substituent effect in palladium/pyridinyl-oxazolines catalyzed asymmetric allylic alkylation. Li, Z.; Tang, F.; Xu, H-D.; Wu, X.; Zhou, Q. *; Chan, A. S. C. J. Mol. Catal. A. 2002, 1-7, 3756.

11．A short synthesis of the HIV-protease inhibitor nelfinavir via a distereoselective addition of ammonia to the α-β-unsaturated sulfoxide derived from (R)-glyceraldehyde acetonide. Ma, D. *; Zou, B.; Zhu, W.; Xu, H-D. Tetrahedron Lett. 2002, 43, 8511.

12．Asymmetric hydroarylation of norbornene derivatives catalyzed by palladium complexes of chiral quinolinyl-oxazolines. Wu, X.; Xu, H-D.; Tang, F.; Zhou, Q．* Tetrahedron Asymmetry 2001, 12, 2565.

13．Enantioselecive Heck-type hydroarylation of norbornene with phenyl iodide catalyzed by palladium/quinolinyloxazolines. Wu, X.; Xu, H-D.; Zhou, Q. *; Chan, A. S. C. Tetrahedron: Asymmetry 2000, 11, 1255.

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