CONTACT( 聯(lián)絡(luò)信息) ：

School of Pharmaceutical and Life Sciences

Changzhou University

Changzhou, Jiangsu 213164, China

Tel：(0519) 86334598

Email： xinchen@cczu．edu．cn

RESEARCH INTERESTS ( 研究方向) ：

1． Drug discovery for treating infection and tumors;

(新型抗生素和抗癌藥物研究)

2． Synthesis of small molecules with important biological activities．

(具有重要生物活性有機小分子的合成方法研究)

PROFESSIONAL EXPERIENCE ( 工作經(jīng)歷) ：

2010- Professor of Chemistry

School of Pharmaceutical and Life Sciences, Changzhou University, China．

(常州大學(xué)制藥學(xué)院)

2004-2010 Director of Small Molecule Synthesis Facility & Assistant Research Professor

Department of Chemistry, Duke University, North Carolina, USA．

(美國杜克大學(xué)化學(xué)系)

2001-2003Senior Research Scientist

TransTech Pharma Inc．, North Carolina, USA．

(美國TransTech Pharma制藥公司)

2000-2001Postdoctoral Research Associate

Department of Chemistry, Duke University, North Carolina, USA

(美國杜克大學(xué)化學(xué)系)

1997-1999Postdoctoral Fellow

Department of Entomology, University of California, Riverside, California, USA

(美國加州大學(xué)河濱分校昆蟲學(xué)系)

1995-1997Associate Professor

Department of Chemistry, Tsinghua University, Beijing, China

(清華大學(xué)化學(xué)系)

1993-1995Postdoctoral Researcher

Department of Chemistry, Tsinghua University, Beijing, China

(清華大學(xué)化學(xué)系)

TEACHING EXPERIENCE ( 授課經(jīng)歷) ：

· “Medicinal Chemistry藥物化學(xué)” (for undergraduate students, 2011)

Changzhou University, China．

· “FDA Regulations for New Drugs新藥認(rèn)證” (for undergraduate students, 2010)

Changzhou University, China．

· “Design of Organic Molecules有機分子設(shè)計” (for undergraduate students, 1995-1997)

Tsinghua University, China．

· “Organic Synthesis有機合成” (for graduate students, 1995-1997)

Tsinghua University, China．

EDUCATIONBACKGROUND (教育背景)：

1993, Ph．D． (Major： synthetic organic chemistry), Lanzhou University, China．

(蘭州大學(xué)化學(xué)系) Advisor： Yulin Li

1990, M．Sc． (Major： organic chemistry), Lanzhou University, China．

(蘭州大學(xué)化學(xué)系) Advisor： Ziyi Zhang

1987, B．Sc． (Major： organic chemistry), Lanzhou University, China．

(蘭州大學(xué)化學(xué)系)

AWARDS AND RECOGNITIONS ( 獲獎榮譽) ：

1、Excellent advisor of undergraduate thesis for Class of 2012, Changzhou University．

(常州大學(xué)2012屆本科畢業(yè)論文優(yōu)秀指導(dǎo)教師)

2、Excellent advisor of undergraduate thesis for Class of 2011, Changzhou University．

(常州大學(xué)2011屆本科畢業(yè)論文優(yōu)秀指導(dǎo)教師)

3、Second-level talented scientist of “333 High-level Talent Training Program” of Jiangsu Province

(江蘇省“333高層次人才培養(yǎng)工程” 第二層次培養(yǎng)對象) (2011-2015)

4、Innovative and entrepreneurial talent of Jiangsu Province (2009)

(江蘇省“雙創(chuàng)人才”)

5、Science and technology leader of “831 Talent Training Program” of Changzhou City (2009)

(常州市“831高層次人才培養(yǎng)工程”首批中青年科學(xué)技術(shù)帶頭人)

6、Team recognition accomplishment award, TransTech Pharma Inc．, USA (2003)

(美國TransTech Pharma公司團隊成就獎)

7、Science and technology progress prize (3rd place), Ministry of Education of China (1997)

(教育部科技進(jìn)步獎三等獎)

8、Science and technology progress prize (2nd place), Gansu Province (1996)

(甘肅省科技進(jìn)步獎二等獎)

9、Science and technology progress prize (1st place), higher-educational institutions of Gansu Province (1996)

(甘肅省高等學(xué)校科技進(jìn)步獎一等獎)

FUNDINGS ( 基金課題) ：

1． National Science Foundation of China project (grant No． 21272029)： “Study on novel inhibitors of type III secretion system for Pseudomonas aeruginosa” (2013-2016, PI)

國家自然科學(xué)基金面上項目(代號21272029)： “綠膿桿菌III型分泌系統(tǒng)的新抑制劑研究” (2013-2016，主持)。

2． National Science Foundation of China project (grant No． 81272982)： “Structure-activity relationship study of Garcinol for oral cancer chemoprevention” (2013-2016, Co-PI)

國家自然科學(xué)基金面上項目(代號81272982)： “山竹醇在口腔癌化學(xué)預(yù)防中的構(gòu)效關(guān)系研究” (2013-2016，合作主持)。

3． Sino-USA international collaborative project： “Synthesis and screening of new inhibitors againstT3SS of pathogens” (2012-2014, PI)

中美國際合作項目：“病原菌III型分泌系統(tǒng)新抑制劑的合成和篩選” (2012-2014，主持)。

4． Technology Supporting Program of Jiangsu Province project： “Efficient sex pheromone technology and its application for pollution-controlling management of vegetable pests” (2012-2014, PI)

江蘇省科技支撐計劃項目： “無公害防治蔬菜害蟲的高效生物信息素技術(shù)及應(yīng)用開發(fā)”(2012-2014，主持)

5． National Science Foundation of USA project (grant No． EAR0921313)： “Defining critical roles of siderophore structures in environmental trace metal cycling (2009-2012, Sub-Contract)．

美國NSF項目(代號EAR0921313)： “自然界微量金屬循環(huán)中鐵載物的關(guān)鍵作用” (2009-2012，合作)。

6． National Science Foundation of China project (grant No． 29602004)： “Study on new synthetic methods for oligonucleotides (1997-1999, PI)

國家自然科學(xué)基金青年基金項目(代號29602004)： “寡核甘酸新的化學(xué)合成方法研究” (1997-1999，主持)。

SELECTED PUBLICATIONS ( 學(xué)術(shù)論文) ：

1． Xin Chen, Xinyan Zhang, Ye Lu, Joong-Youn Shim, Shengmin Sang, Zheng Sun, Xiaoxin Chen, “Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Hamster Cheek Pouch Carcinogenesis by a 5-Lipoxygenase Inhibitor, Garcinol”, Nutrition & Cancer (in press, 2012)．

2． Jie Ren, Hong Cheng, Wen Qun Xin, Xin Chen*, Kun Hu*, “Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells”, Oncology Reports, 2012, 28, 1719-1726．

3． Jie Ren, Hua-Jin Xu, Hong Cheng, Wen-Qun Xin，Xin Chen*, Kun Hu*, “Synthesis and antitumor activity of Formononetin nitrogen mustard derivatives”, Eur． J． Med． Chem． 2012, 54, 175-187．

4． Kun Hu, Lin Wu, Wen-Qun Xin, Xin Chen*, Jie Ren*,“Synthesis and biological evaluation of anticancer activity for novel 4β-amino oxadiazole derivatives of podophyllotoxin”, Bioorg． Med． Chem． Lett． 2012, 22, 4778-4782．

5． Tian-Li Chen, Xiao-Yang Yu, Xiang Zhao, Yu-Hui Luo, Jia-Jun Yang, Hong Zhang*, Xin Chen*, “Syntheses, structures and luminescence properties of two series of 3D lanthanide coordination polymers based on benzimidazole-5,6-dicarboxylic acid and oxalate”, Inorg． Chem． Commun． 2012, 18, 74-77．

6． Xiang Zheng, Sheng-Qi Guo, Xiao-Yang Yu, Ju-Kun Hu, Yu-Hui Luo, Hong Zhang*, Xin Chen*, “Two zinc(II) coordination polymers based on a benzenedicarboxylic acid derivative： synthesis, crystal structures and luminescent properties”, Inorg． Chem． Commun． 2012, 18, 29-33．

7． Akihiro Yamazaki, Jin Li, Quan Zeng, Devanshi Khokhani, William C． Hutchins, Angela C． Yost, Eulandria Biddle, Eric J． Toone, Xin Chen*, Ching-Hong Yang*, “Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS/GacA two component signal transduction system”, Antimicrob． Agents Chemother． 2012, 56, 36-43．

8． Xin Chen*, Zhengyi Li, Xiaoqiang Sun, Hongzhao Ma, Xiaoxin Chen, Jie Ren, Kun Hu, “New method for synthesis of sulforaphane and the related isothiocyanates”, Synthesis, 2011, 3991-3996．

9． Bidong D． Nguyen, Doreen F． Cunningham, Xiaofei Liang, Xin Chen, Eric J． Toone, Christian R． H． Raetz, Pei Zhou, Raphael H． Valdivia, “Lipooligosaccharide is required for the developmental transition of replicative Reticulate Bodies to infectious Elementary Bodies in Chlamydia trachomatis”, Proc． Natl． Acad． Sci． USA, 2011, 108, 10284-10289．

10．Chuljin Lee, Xiaofei Liang, Xin Chen, Daina Zeng, Sang Hoon Joo, Hak Suk Chung, Adam W． Barb, Shauna M． Swanson, Robert A． Nicholas, Yaoxian Li, Eric J． Toone, Chris Raetz, Pei Zhou, “Species-specific and Inhibitor-dependent Conformations of LpxC--Implication for Antibiotic Design”, Chemistry & Biology, 2011, 18, 38-47．

11．Xiaofei Liang, Chul-Jin Lee, Xin Chen, Hak Suk Chung, Daina Zeng, Christian R． H． Raetz, Yaoxian Li, Pei Zhou, Eric J． Toone, “Syntheses, Structures and Antibiotic Activities of LpxC Inhibitors Based on the Diacetylene Scaffold”, Bioorg． Med． Chem． 2011, 19, 852-860．

12．Artak Tovmasyan, Zrinka Rajic, Ivan Spasojevic, Julio S． Reboucas, Xin Chen, Huaxin Sheng, David S． Warner, Ludmil Benov, Ines Batinic-Haberle, “ Methoxy-derivatization of alkyl chains increases the efficacy of cationic Mn porphyrins．Synthesis, characterization, SOD-like activity, and SOD-deficient E． coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins”, J． Chem． Soc． Dalton Trans． 2011, 40, 4111-4121．

13．Warren S． Warren, Elizabeth Jenista, Rosa Tamara Branca, Xin Chen, “Increasing hyperpolarized spin lifetimes through true singlet eigenstates”, Science, 2009, 323, 1711-1714．

14．J． R． Aldrich, A． K． Hrimian, X． Chen, M． J． Camp, “Semiochemically based monitoring of the invasion of the brown marmorated stink bug and unexpected attraction of the native green stink bug (Heteroptera： Pentatomidae) in Maryland”, Florida Entomologist, 2009, 92, 483-491．

15．John J． Arnold, Yash Choksi, Xin Chen, Atsushi Shimazaki, John Hatten, Eric J． Toone, David L． Epstein, Pratap Challa, “Eyedrops containing SA9000 prodrugs result in sustained reduction in intraocular pressure in rabbits”, J． Ocular Pharmacology & Therapeutics, 2009, 25, 179-186．

16．Yan Li, Quan Peng, Dija Selimi, Qi Wang, Amy Charkowski, Xin Chen, Ching-Hong Yang, “The plant phenolic compound p-coumaric acid represses gene expression in the Dickeya dadantii type III secretion system”, Applied & Environmental Microbiology, 2009, 75, 1223-1228．

17．Weslyn C． Ward, Erin C． Lamb, David Gooden, Xin Chen, David J． Burinsky, John D． Simon, “Quantification of naturally occurring pyrrole acids in melanosomes”, Photochemistry & Photobiology, 2008, 84, 700-705．

18．Heather L． McBrien, Jocelyn G． Millar, Levi Gottlieb, Xin Chen, Richard E． Rice, “Male-produced sex attractant pheromone of the green stink bug, Acrosternum hilare (Say)”, J． Chem． Ecol． 2001, 27, 1821-1839．

19．Xin Chen, Jocelyn G． Millar, “Preparative scale syntheses of isomerically pure (10E,12E,14Z)- and (10E,12E,14E)-hexadeca-10,12,14-trienals, sex pheromone components of Manduca sexta”, Synthesis, 2000, 113-118．

20．Xin Chen, Levi Gottlieb, Jocelyn G． Millar, “Highly stereoselective syntheses of the sex pheromone components of the southern green stink bug Nezara viridula (L．) and the green stink bug Acrosternum hilare (Say)”, Synthesis, 2000, 269-272．

21．J． Steven McElfresh, Xin Chen, Darrell W． Ross, Jocelyn G． Millar, "Sex pheromone blend of the pandora moth Coloradia pandora, an outbreak pest in pine forests in the western United States", Canadian Entomologist, 2000, 132, 775-787．

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