廣西醫(yī)科大學(xué)國家生物靶向診治國際聯(lián)合中心、基礎(chǔ)醫(yī)學(xué)院導(dǎo)師：周靜 正文

[導(dǎo)師姓名]
周靜

[所屬院校]
廣西醫(yī)科大學(xué)

[基本信息]
導(dǎo)師姓名：周靜
性別：女
人氣指數(shù)：3230
所屬院校：廣西醫(yī)科大學(xué)
所屬院系：國家生物靶向診治國際聯(lián)合中心、基礎(chǔ)醫(yī)學(xué)院
職稱：教授
導(dǎo)師類型：碩導(dǎo)/博導(dǎo)
招生專業(yè)：生理學(xué)、醫(yī)學(xué)生物化學(xué)與分子生物學(xué)、醫(yī)學(xué)生理學(xué)
研究領(lǐng)域：1.腫瘤的發(fā)病機(jī)理以及植物藥的抗癌機(jī)理研究2.代謝疾病（肥胖以及糖尿病）的發(fā)病機(jī)理，以及營...

[通訊方式]


[個(gè)人簡(jiǎn)述]
周靜，女，博士，于2010年畢業(yè)于新加坡國立大學(xué)醫(yī)學(xué)院，獲得細(xì)胞分子生物學(xué)博士學(xué)位，隨后五年先后就職于新加坡國立大學(xué)以及南洋理工大學(xué)，進(jìn)行博士后培訓(xùn)。以第一作者和共同作者于Cell?Research，Autophagy，Hepatology，Molecular?Cancer?Therapeutics以及Biological?Pharmacology等高水平國際期刊上發(fā)表SCI論文20篇。在從事科研工作的12年間，建立了自噬-溶酶體調(diào)控機(jī)制、植物藥調(diào)控凋亡以及自噬的抗癌機(jī)理、自噬與脂類代謝等研究平臺(tái)。2014年通過廣西高?！鞍偃擞?jì)劃”人才引進(jìn)回國，開展科研教學(xué)工作。目前就職于廣西醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)學(xué)院生理教研室，擔(dān)任生理學(xué)、實(shí)驗(yàn)生理學(xué)的教學(xué)工作；主持廣西高?！鞍偃擞?jì)劃”專項(xiàng)課題,國家自然基金項(xiàng)目以及廣西自然科學(xué)基金項(xiàng)目共三項(xiàng)。具有14年中西醫(yī)結(jié)合基礎(chǔ)醫(yī)學(xué)以及應(yīng)用細(xì)胞分子生物的科研經(jīng)驗(yàn)，實(shí)驗(yàn)水平全面，具備獨(dú)立工作以及領(lǐng)導(dǎo)能力，重視團(tuán)隊(duì)合作精神，善于協(xié)調(diào)溝通。良好的中英文書寫、演講交流能力。

[科研工作]
已發(fā)表的代表性論文：[1]?Zhou?J#,Tang?Y,Xie?ZJ,Lu?JN,Deng?JH,Huang?XW,Chuan?Hooi?S,He?M,Lu?GD＊.?AKT?activation?was?not?essential?for?hepatocellular?carcinoma?cell?survival?under?glucose?deprivation.?Anticancer?Drugs.2017?Apr28(4):427-435.?（IF?2.268）[2]?Shi?Y#,?Tan?SH,?Ng?S,?Zhou?J,?Yang?ND,?Koo?GB,?Mcmahon?KA,?Parton?RG,?Hill?MM,?Del?PozoMA,?Kim?YS,?Shen?HM＊.?Critical?role?of?CAV1/caveolin-1?in?cell?stress?responses?in?human?breast?cancer?cells?via?modulation?of?lysosomal?function?and?autophagy.?Autophagy.?2015?11(5):769-84.?（IF?9.108）[3]?Zhang?J#,?Ng?S,?Wang?J,?Zhou?J,?Tan?SH,?Yang?N,?Lin?Q,?Xia?D,?Shen?HM＊.?Histone?deacetylase?inhibitors?induce?autophagy?through?FOXO1-dependent?pathways.?Autophagy.?2015?Apr?311(4):629-42.?（IF?9.108）[4]?Lu?GD＊#,?Ang?YH,?Zhou?J,?Tamilarasi?J,?Yan?B,?Lim?YC,?Srivastava?S,?Salto-Tellez?M,?Hui?KM,?Shen?HM,?Nguyen?LN,?Tan?BC,?Silver?DL,?Hooi?SC＊.?C/EBPalpha?predicts?poorer?prognosis?and?prevents?energy?starvation-induced?cell?death?in?hepatocellular?carcinoma.?Hepatology.?2015?61(3):?965-78.（IF?11.711）[5]?Yang?ND,?Tan?SH,?Ng?S,?Shi?Y,?Zhou?J,?Tan?KS,?Wong?WS,?Shen?HM.?Artesunate?induces?cell?death?in?human?cancer?cells?via?enhancing?lysosomal?function?and?lysosomal?degradation?of?ferritin.?J?Biol?Chem.?2014?Nov?28289(48):33425-41.[6]?Tan?SH#,?Shui?G,?Zhou?J,?Shi?Y,?Huang?J,?Xia?D,?Wenk?MR,?Shen?HM＊.?Critical?role?of?SCD1?in?autophagy?regulation?via?lipogenesis?and?lipid?rafts-coupled?AKT-FOXO1?signaling?pathway.?Autophagy.?2014?Feb10(2):226-42.（IF?9.108）[7]?Wang?J#,?Tan?XF.,?Nguyen?VS,?Yang?P,?Zhou?J,?Gao?M,?Li?Z,?Lim?TK.,?He?Y,?Ong?CS,?Zhang?J,?Zhu?G,?Lai?SL,?Ghosh?D,?Mok?YK,?Shen?HM,?Lin?Q＊.?(2014).?A?quantitative?chemical?proteomics?approach?to?profile?the?specific?cellular?targets?of?andrographolide,?a?promising?anticancer?agent?that?suppresses?tumor?metastasis.?Mol?Cell?Proteomics?13,?876-886.?(IF?6.5641)[8]?Zhou?J#,?Tan,?SH,?Codogno?P,?and?Shen?HM＊.?Dual?suppressive?effect?of?mTORC1?on?autophagy:?tame?the?dragon?by?shackling?both?the?head?and?the?tail.?Autophagy?2013.?2013?May9(5):803-5.?（IF?9.108）[9]?Zhou?J#,?Tan?SH,?Nicolas?V,?Bauvy?C,?Yang?ND,?Zhang?J,?Xue?Y,?Codogno?P,?Shen?HM＊.?Activation?of?lysosomal?function?in?the?course?of?autophagy?via?mTORC1?suppression?and?autophagosome-lysosome?fusion.?Cell?Res?2013?Apr23(4):508-23.?（IF?14.812）[10]?Zhou?J#,?Ng?S,?Huang?Q,?Wu?YT,?Li?Z,?Yao?SQ,?Shen?HM＊.?AMPK?mediates?a?pro-survival?autophagy?downstream?of?PARP-1?activation?in?response?to?DNA?alkylating?agents.?FEBS?Lett.?16587(2):170-7,?2013.?（IF?3.519）[11]?Tan?SH#,?Shui?G,?Zhou?J,?Li?JJ,?Bay?BH.,?Wenk?MR.,?and?Shen?HM＊.?Induction?of?autophagy?by?palmitic?acid?via?protein?kinase?C-mediated?signaling?pathway?independent?of?mTOR?(mammalian?target?of?rapamycin).?J?Biol?Chem?287,?14364-14376,?2012.?（IF?4.258）[12]?Zhang?Y#,?Yang?ND,?Zhou?F,?Shen?T,?Duan?T,?Zhou?J,?Shi?Y,?Zhu?XQ,?Shen?HM＊.?(-)-Epigallocatechin-3-gallate?induces?non-apoptotic?cell?death?in?human?cancer?cells?via?ROS-mediated?lysosomal?membrane?permeabilization.?PLoS?One.?7(10):e46749,?2012.?(IF??3.730)[13]?Zhou?J1#,?Hu?SE1#,?Tan?SH,?Cao?R,?Chen?Y,?Xia?D,?Zhu?X,?Yang?XF,?Ong?CN,?Shen?HM＊.?Andrographolide?sensitizes?cisplatin-induced?apoptosis?via?suppression?of?autophagosome-lysosome?fusion?in?human?cancer?cells.?Autophagy?8:?338-349,?2012.?（IF?9.108）*共同第一作者[14]?Ng?SK,?Chen?B,?Wu?YT,?Zhou?J,?Shen?HM.?Constitutive?mTOR?activation?suppresses?autophagy?and?sensitizes?TSC2-null?cells?to?cell?death.?Autophagy?7:1173-86,?2011.[15]?Zhou?J,?Ong?CN,?Hur?GM,?Shen?HM.?Inhibition?of?the?JAK-STAT3?pathway?by?andrographolide?enhances?chemosensitivity?of?cancer?cells?to?doxorubicin.?Biochem?Pharmacol?79(9):1242-50?2010.?（IF?5.091）[16]??Ong?CS,?Zhou?J,?Ong?CN,?Shen?HM.?Luteolin?induces?G1?arrest?in?human?nasopharyngeal?carcinoma?cells?via?the?Akt-GSK-3?beta-Cyclin?D1?pathway.?Cancer?Letters?298(2):?167-75?2010.?(IF?4.248)[17]?Zhou?J,?Lu?GD,?Ong?CS,?Ong?CN,?Shen?HM.?Andrographolide?sensitizes?cancer?cells?to?TRAIL-induced?apoptosis?via?p53-mediated?death?receptor?4?up-regulation.?Mol?Cancer?Ther??7(7):?2170-80.?（IF?5.579）[18]?Zhou?J,?Zhang?S,?Ong?CN,?Shen?HM.?Critical?role?of?pro-apoptotic?Bcl-2?family?members?in?andrographolide-induced?apoptosis?inhuman?cancer?cells.?Biochem?Pharmacol?72:132-144?2006.?（IF?5.091）[19]?Zhou?J,?Xiao?C,?Zhao?L,Jia?H,?Zhao?N,?Lu?C,?Yang?D,?Tang?JC,?Chan?AS,?Lu?AP.?The?effect?of?triptolide?on?CD4+?and?CD8+?cells?in?Peyer's?patch?of?SD?rats?with?collagen?induced?arthritis.?Int?Immunopharmacol?6(2):198-203?2006.?（IF?2.551）。

[教育背景]
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