廣州醫(yī)科大學(xué)導(dǎo)師：夏學(xué)鋒 正文

[導(dǎo)師姓名]
夏學(xué)鋒

[所屬院校]
廣州醫(yī)科大學(xué)

[基本信息]
導(dǎo)師姓名：夏學(xué)鋒
性別：男
人氣指數(shù)：588
所屬院校：廣州醫(yī)科大學(xué)
所屬院系：
職稱(chēng)：教授
導(dǎo)師類(lèi)型：博導(dǎo)
招生專(zhuān)業(yè)：婦產(chǎn)科學(xué)

[通訊方式]


[個(gè)人簡(jiǎn)述]
夏學(xué)鋒，教授，博士生導(dǎo)師。美國(guó)TheMethodistHospitalResearchInstitute基因組醫(yī)學(xué)中心（CenterforGenomicMedicine）和糖尿病研究中心(CenterforDiabetesResearch)的研究員（Scientist）。美國(guó)胃腸病協(xié)會(huì)(AGA)會(huì)員，美國(guó)肝臟病研究協(xié)會(huì)（AASLD）會(huì)員，美國(guó)內(nèi)分泌學(xué)會(huì)（TheEndocrineSociety）會(huì)員。擔(dān)任《Gastroenterology》、《Hepatology》、《Gut》、《AmericanJournalofPhysiology》、《AJP-GastrointestinalandLiverPhysiology》、《DigestiveandLiverDisease》等雜志審稿人。1998-2002年于美國(guó)貝勒醫(yī)學(xué)院（BaylorCollegeofMedicine）完成PostdoctoralAssociate培訓(xùn)，曾擔(dān)任德州大學(xué)休士頓醫(yī)學(xué)院（UniversityofTexasHealthScienceCenteratHouston）醫(yī)學(xué)系講師(Instructor)和助理教授（AssistantProfessor）。已經(jīng)培養(yǎng)博士研究生2名和博士后研究生8名。蘭州大學(xué)萃英講習(xí)教授和廣州醫(yī)學(xué)院特聘教授。主持完成課題9項(xiàng)，參與美國(guó)國(guó)立衛(wèi)生研究所（NIH）項(xiàng)目5項(xiàng)，繼續(xù)承擔(dān)NIH課題和美國(guó)國(guó)防部課題2項(xiàng)，合作科研項(xiàng)目2項(xiàng)，發(fā)表ProcNatlAcadSciUSA,Cell,JClinInvest,Oncogene,CircRes,JBiolChem及Heptology有等高水平學(xué)術(shù)期刊論文40余篇，曾多次受邀在A&MUniversitySystemHealthScienceCenter、MDAndersonCancerCenter,UniversityofHouston、中南大學(xué)、廣州醫(yī)學(xué)院、華東師范大學(xué)、溫州醫(yī)學(xué)院、蘭州大學(xué)及其他科研機(jī)構(gòu)做專(zhuān)題報(bào)告，并多次參加國(guó)際會(huì)議交流并大會(huì)發(fā)言，論文獲大會(huì)頒獎(jiǎng)。2011年作為特邀嘉賓在東方內(nèi)分泌-糖尿病論壇和中華內(nèi)分泌年會(huì)大會(huì)報(bào)告。從事核激素受體（NuclearHormoneReceptor）在腫瘤、人體代謝，生殖內(nèi)分泌調(diào)控，及肝膽疾病和腎臟疾病等領(lǐng)域的創(chuàng)新性研究，并取得卓著的成績(jī)。

[科研工作]
部分發(fā)表的論文：?XiaX,JungD,WebbP,ZhangA,ZhangB,LiL,AyersSD,GabbieC,UenoY,GustafssoneJ,AlpiniG,MooreDD,LeSageGD.?LiverXReceptorβandPeroxisomeProliferator-ActivatedReceptorδregulatecholesteroltransportincholangiocytes.????Hepatology.?2012Jun22.doi:10.1002/hep.25919.[Epubaheadofprint]YuB,LinH,YangL,ChenK,LuoH,LiuJ,GaoX,XiaX,HuangZ.GeneticvariationinNRF2-AREpathwayassociateswithdefectivespermatogenesisinhumans.?JMolMed(Berl).2012May31.[Epubaheadofprint]WangF,YuB,YangW,LiuJ,LuJ,XiaX.Polycysticovarysyndromeresemblinghistopathologicalalterationsinovariesfromprenatalandrogenizedfemalerats.?JOvarianRes.2012May185(1):15.[Epubaheadofprint]LiL,ZhangX,ZhaoL,XiaX,WangW.??ComparisonofDNAapoptosisinmouseandhumanblastocystsaftervitrificationandslowfreezing.?MolReprodDev.2012Feb1,79:229?236?ZhouY,TozziF,ChenJ,FanF,XiaL,WangJ,GaoG,ZhangA,XiaX,BrasherH,WidgerW,EllisLM,WeihuaZ.?IntracellularATPlevelsareapivotaldeterminantofchemoresistanceincoloncancercells.?CancerRes.2012Jan172(1):304-14.?SandulacheVC,SkinnerHD,OwTJ,ZhangA,XiaX,LuchakJM,WongLJ,PickeringCR,ZhouG,MyersJN.???Individualizinganti-metabolictreatmentstrategiesforheadandnecksquamouscellcarcinomabasedonTP53mutationalstatus.?Cancer.2012Feb1118(3):711-21.?DengT,SieglaffDH,ZhangA,LyonCJ,AyersSD,CvoroA,GupteAA,XiaX,BaxterJD,WebbP,HsuehWA.???Aperoxisomeproliferatoractivatedreceptor(PPAR)/PPARcoactivator1βautoregulatoryloopinadipocytemitochondrialfunction.JBiolChem.2011Sep2286(35):30723CollinsAR,LyonCJ,XiaX,LiuJZ,TangiralaRK,YinF,BoyadjianR,BikineyevaA,PraticòD,HarrisonDG,HsuehWA.Age-acceleratedatherosclerosiscorrelateswithfailuretoupregulateantioxidantgenes.CircRes.2009Mar27104(6):e42-54.ZhongX,LiuH,PuA,XiaX,ZhouX.Mcellsareinvolvedinpathogenesisofhumancontactlens-associatedgiantpapillaryconjunctivitis.ArchImmunolTherExp(Warsz).2007May55(3):173-7.?ZhangW,XiaX,ReisenauerMR,VallonV,LangF,KuhlD,KoneBC.Aldosterone-inducedSGK1PhosphorylatesAF9andRelieves?Dot1a-AF9-MediatedTranscriptionalRepressionofENaCalpha.??JClinInvest.2007Mar117(3):773-83.?ZhangW,XiaX,ReisenauerMR,HemenwayCS,KoneBC.DOT1a-AF9complexmediateshistoneH3K79hypermethylationandrepressionofENaCαinanaldosterone-sensitivemanner.?JBiolChem.2006Jun30281(26):18059-68.?MaW,XiaX,StaffordLJ,YuC,WangF,LeSageG,LiuM.ExpressionofGCIPintransgenicmicedecreasessusceptibilitytochemicalhepatocarcinogenesis.?Oncogene.2006Jul1325(30):4207-16.ZhangW,XiaX,JalalDI,KuncewiczT,XuW,LeSageGD,KoneBC.??Aldosterone-sensitiverepressionofENaCαtranscriptionbyahistoneH3lysine-79methyltransferase.AmJPhysiolCellPhysiol.2006Mar290(3):C936-46.?AlpiniG,GlaserS,BaiocchiL,FrancisH,XiaX,LeSageG.???SecretinactivationoftheapicalNa(+)-dependentbileacidtransporterisassociatedwithcholehepaticshuntinginrats.??Hepatology.2005May41(5):1037-45.??YuZ,XiaX,KoneB.?ExpressionProfileofaHumanInducibleNitricOxideSynthasePromoter-ReporterInTransgenicMiceDuringEndotoxemia.?AmJPhysiolRenalPhysiol.2005Jan288(1):F214-20.?XiaX,RoundtreeM,MerikhiA,LuX,ShentuS,LeSageG.??DegradationoftheApicalSodium-dependentBileAcidTransporter(ASBT)bytheUbiquitin-ProteasomePathwayinCholangiocytes.?JBiolChem.2004279(43):44931-44937.?ZhangW,XiaX,ZouL,XuX,LeSageGD,andKoneBC.??InVivoExpressionProfileofanH+-K+-ATPase2SubunitPromoter-reporterTransgene.??????JPhysiolRenalPhysiol.2004Jun286(6):F1171-77.?QyangY,ChambersSM,WangP,XiaX,ChenX,GoodellMA,ZhengH.??Myeloproliferativediseaseinmicewithreducedpresenilingenedosage:effectofgamma-secretaseblockage.?Biochemistry.2004May1143(18):5352-9.?KangDE,SorianoS,XiaX,EberhartCG,DeStrooperB,ZhengH,KooED.Presenilincouplesthepairedphosphorylationofbeta-cateninindependentofaxin:implicationsforbeta-cateninactivationintumorigenesis.??Cell.2002Sep20110(6):751-62.XiaX,WangP,SunX,SorianoS,ShumWK,YamaguchiH,TrumbauerME,TakashimaA,KooEH,ZhengH.Theaspartate-257ofpresenilin1isindispensableformousedevelopmentandproductionofbeta-amyloidpeptidesthroughbeta-catenin-independentmechanisms.ProcNatlAcadSciUSA.2002Jun2599(13):8760-5.?MoehlmannT,WinklerE,XiaX,EdbauerD,MurrellJ,CapellA,KaetherC,ZhengH,GhettiB,HaassC,SteinerH.Presenilin-1mutationsofleucine166equallyaffectthegenerationoftheNotchandAPPintracellulardomainsindependentoftheireffectonAbeta42production.ProcNatlAcadSciUSA.2002Jun1199(12):8025-30.?DineleyKT,XiaX,BuiD,SweattJD,ZhengH.?Acceleratedplaqueaccumulation,associativelearningdeficits,andup-regulationofalpha7nicotinicreceptorproteinintransgenicmiceco-expressingmutanthumanpresenilin1andamyloidprecursorproteins.?JBiolChem.2002Jun21277(25):22768-80.?XiaX,QianS,SorianoS,WuY,FletcherAM,WangXJ,KooE,WuX,ZhengH.Lossofpresenilin1isassociatedwithenhancedbeta-cateninsignalingandskintumorigenesis.???ProcNatlAcadSciUSA.2001Sep1198(19):10863-8.?Books,BookChaptersandReviews?XiaX,FrancisH,GlaserS,AlpiniG,LeSageG.Bileacidinteractionswithcholangiocytes.WorldJGastroenterol.200612(22):3553-3563.?XiaX,DeMorrowS,MarzioniM,FavaG,FrancisH,AlpiniG,GlaserS,LeSageG.CholangiocyteInjuryandDuctopenicSyndromes.SeminLiverDis.2007Nov27(4):401-12.XiaX,AlpiniG,LeSageG.???“ExtrahepatocyticTransportofBileAcids:TheRoleoftheCholangiocyte”.In:KepplerD,BeuersU,LeuschnerU,StiehlA,TraunerM,PaumgartnerG,eds.Bileacids:biologicalactionsandclinicalrelevance.ProceedingsoftheFalkSymposium1552006Oct6-7Freiberg(Germany).Dordrecht(TheNetherlands):Springer2007:71-75XiaX,LeSageG.,“Bileacidsandcholangiocytebiology”inPathophysiologyoftheIntrahepaticBiliaryEpithelium.??2008:ISBN:978-81-7895-337-3??TransworldResearchNetwork37/661(2),FortP.O.,Trivandrum-695023,Kerala,India???2009:1-20

[教育背景]

廣州醫(yī)科大學(xué)

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