河北醫(yī)科大學(xué)導(dǎo)師：許順江 正文

[導(dǎo)師姓名]
許順江

[所屬院校]
河北醫(yī)科大學(xué)

[基本信息]
導(dǎo)師姓名：許順江
性別：男
人氣指數(shù)：579
所屬院校：河北醫(yī)科大學(xué)
所屬院系：
職稱：教授
導(dǎo)師類型：
招生專業(yè)：病理學(xué)與病理生理學(xué)

[通訊方式]
辦公電話：0311 8591 7257
電子郵件：sjxu66@sina.com

[個(gè)人簡(jiǎn)述]
本人2005年獲河北醫(yī)科大學(xué)病理生理學(xué)系醫(yī)學(xué)博士學(xué)位，導(dǎo)師：叢 斌 院士。2005年8月-2008年8月，在澳大利亞新南威爾士大學(xué)做博士后。近年來主要從事病理生理學(xué)和神經(jīng)科學(xué)方面的研究工作。研究領(lǐng)域包括非編碼RNA在神經(jīng)退行性疾病和糖尿病視網(wǎng)膜病變發(fā)病中的作用及分子機(jī)制。特別是在老年癡呆研究方面取得重要進(jìn)展，率先在我省4個(gè)城市12個(gè)行政區(qū)36個(gè)社區(qū)進(jìn)行了大規(guī)模的流行病學(xué)調(diào)查，篩選出老年癡呆的易感人群，并分析了我省老年癡呆發(fā)病的相關(guān)危險(xiǎn)因素，通過大量實(shí)驗(yàn)篩選出用于早期識(shí)別輕度認(rèn)知功能障礙的生物標(biāo)志物，為老年癡呆的早期診斷提供了依據(jù)，同時(shí)建立了完善的資料庫和標(biāo)本庫。在國際知名雜志《Journal of Alzheimer’s Disease》（該雜志5年影響因子4.394，中科院JCR大類二區(qū)）上發(fā)表了4篇系列研究文章。現(xiàn)在主持國家自然科學(xué)基金面上項(xiàng)目1項(xiàng)、河北省國際合作項(xiàng)目1項(xiàng)、河北省自然科學(xué)基金項(xiàng)目1項(xiàng)、河北省應(yīng)用基礎(chǔ)研究計(jì)劃重點(diǎn)基礎(chǔ)研究項(xiàng)目1項(xiàng)和省政府資助臨床優(yōu)秀人才培養(yǎng)項(xiàng)目1項(xiàng)以及省衛(wèi)生廳課題多項(xiàng)。作為主研人參與國家自然科學(xué)基金課題2項(xiàng)。近五年來以第一作者或通訊作者發(fā)表文章20篇，其中SCI收錄10篇，累計(jì)被引用280次。獲得河北醫(yī)學(xué)科技獎(jiǎng)一等獎(jiǎng)2項(xiàng)。申報(bào)國家發(fā)明專利三項(xiàng)，已受理待批準(zhǔn)。出版專著兩部。兼任河北省實(shí)驗(yàn)動(dòng)物學(xué)會(huì)常務(wù)理事、河北省醫(yī)學(xué)會(huì)理事和河北省醫(yī)學(xué)會(huì)檢驗(yàn)醫(yī)學(xué)分會(huì)委員。任《Journal of Alzheimer’s Disease》助理編輯、《Acta Pharmacologica Sinica》和《Invest Ophthalmol Vis Sci》特約審稿人。

[科研工作]
發(fā)表論文情況 以第一或通訊作者發(fā)表文章如下：1. Zhang R, Garrett Q, Zhou H, Wu X, Mao Y, Cui X, Xie B, Liu Z, Cui D, Jiang L, Zhang Q, Xu S. Upregulation of miR-195 accelerates oxidative stress-induced retinal endothelial cell injury by targeting mitofusin 2 in diabetic rats. Mol Cell Endocrinol. 2017 Sep 5452:33-43.2. Xie B, Liu Z, Liu W, Jiang L, Zhang R, Cui D, Zhang Q, Xu S. DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort Study. J Alzheimers Dis. 201758(1):263-274.3. Xie B, Xu Y, Liu Z, Liu W, Jiang L, Zhang R, Cui D, Zhang Q, Xu S. Elevation of Peripheral BDNF Promoter Methylation Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer's Disease: A 5-Year Longitudinal Study. J Alzheimers Dis. 201756(1):391-401. 4. Zhang R, Zhou H, Jiang L, Mao Y, Cui X, Xie B, Cui D, Wang H, Zhang Q, Xu S. MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice.Brain Res. 2016 Dec 11652:135-143. 5. Xie B, Liu Z, Jiang L, Liu W, Song M, Zhang Q, Zhang R, Cui D, Wang X, Xu S. Increased Serum miR-206 Level Predicts Conversion from Amnestic Mild Cognitive Impairment to Alzheimer's Disease: A 5-Year Follow-up Study. J Alzheimers Dis. 201755(2):509-520.6. Zhou H, Zhang R, Lu K, Yu W, Xie B, Cui D, Jiang L, Zhang Q, Xu S. Deregulation of miRNA-181c potentially contributes to the pathogenesis of AD by targeting collapsin response mediator protein 2 in mice. J Neurol Sci. 2016 Aug 15367:3-10.7. Xie B, Zhou H, Zhang R, Song M, Yu L, Wang L, Liu Z, Zhang Q, Cui D, Wang X, Xu S. Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment. J Alzheimers Dis. 201545(3):721-31. 8. Xu S, Xie B, Song M, Yu L, Wang L, An C, Zhu Q, Han K, Zhao X, Zhang R, Dong L, Chai N, Gao Y, Zhang Q, Wang X. High prevalence of mild cognitive impairment in the elderly: a community-based study in four cities of the Hebei province, china. Neuroepidemiology. 201442(2):123-30. 9. Zhang R, Zhang Q, Niu J, Lu K, Xie B, Cui D, Xu S. Screening of microRNAs associated with Alzheimer's disease using oxidative stress cell model and different strains of senescence accelerated mice. J Neurol Sci. 2014 Mar 15338(1-2):57-64.10. Xu S, Zhang R, Niu J, Cui D, Xie B, Zhang B, Lu K, Yu W, Wang X, Zhang Q. Oxidative stress mediated-alterations of the microRNA expression profile in mouse hippocampal neurons.Int J Mol Sci. 2012 Dec 1113(12):16945-60. 11. Zhang R, Niu J, Cui D, Xie B, Zhang B, Lu K, Yu W, Wang X, Zhang Q, Xu S.Neuroprotective Effects of Pre-Treament with L-Carnitine and Acetyl-L-Carnitine on Ischemic Injury In Vivo and In Vitro. Int. J. Mol. Sci. 2012, 13, 2078-2090.

[教育背景]
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河北醫(yī)科大學(xué)

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