蘭州大學(xué)研究生導(dǎo)師：達(dá)朝山 正文

　　學(xué)習(xí)經(jīng)歷

　　2010年3月—2011年3月，美國(guó)賓夕法尼亞大學(xué)化學(xué)系, 訪問學(xué)者，合作者Patrick J. Walsh教授。

　　2000年9月—2003年6月，蘭州大學(xué)生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)研究所，從事博士學(xué)位的學(xué)習(xí)和研究工作，獲得理學(xué)博士學(xué)位，導(dǎo)師王銳教授。

　　1998年9月—2000年6月，蘭州大學(xué)生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)研究所，從事碩士學(xué)位的學(xué)習(xí)和研究工作，獲得理學(xué)碩士學(xué)位，導(dǎo)師王銳教授。

　　1986年9月—1990年6月，蘭州大學(xué)原生物系植物生理專業(yè)學(xué)習(xí)，獲得理學(xué)學(xué)士學(xué)位。

　　工作經(jīng)歷

　　2012-, 蘭州大學(xué)，生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)研究所，教授，博士生導(dǎo)師。

　　2010-2012，蘭州大學(xué)，生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)研究所，副教授，博士生導(dǎo)師。

　　2007-2010，蘭州大學(xué)，生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)研究所，副教授，碩士生導(dǎo)師。

　　2005-2007，蘭州大學(xué)，生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)研究所，講師，碩士生導(dǎo)師。

　　2003-2005，蘭州大學(xué)，生命科學(xué)學(xué)院生物化學(xué)與分子生物學(xué)研究所，講師。

　　1990-1997，甘肅省科學(xué)院，生物研究所，研究實(shí)習(xí)員。

　　教學(xué)及指導(dǎo)研究生情況

　　本科生教學(xué)，主講《生物化學(xué)》

　　發(fā)表論文及專著

　　一、發(fā)表SCI論文情況

　　Pei Wang, Hong-Feng Li, Jia-Zhen Zhao, Zhi-Hong Du, and Chao-Shan Da, Organocatalytic Enantioselective Cross-Aldol Reaction of o-Hydroxyarylketones and Trifluoromethyl Ketones, Org. Lett., 2017, 19, 2634–2637. (pdf)

　　Pei Wang, Yue Liu, Ya-Lun Zhang and Chao-Shan Da, The inexpensive additive N-methylmorpholine effectively decreases the equivalents of nucleophiles in the catalytic highly enantioselective arylation of aryl aldehydes, Chirality 2017, DOI: 10.1002/chir.22709. (pdf)

　　Pei Wang, Jia-Zhen Zhao, Hong-Feng Li, Xiang-Ming Liang, Ya-Lun Zhang, Chao-Shan Da, Acid-catalyzed highly diastereoselective and effective synthesis of 1,3-disubstituted tetrahydropyrano[3,4-b]indoles, Tetrahedron Lett. 2017, 58, 129-133. （pdf）

　　Wen-Wen Xie, Yue Liu, Rui Yuan, Dan Zhao, Tian-Zhi Yu, Jian Zhang, Chao-Shan Da,Transition Metal-Free Homocoupling of Unactivated Electron-Deficient Azaarenes, Adv. Synth. Catal. 2016, 358, 994-1002.(pdf)

　　Long Qin, Pei Wang, Yixin Zhang, Zhengxiang Ren, Xin Zhang, Chao-Shan Da,Direct Asymmetric Friedel–Crafts Reaction of Naphthols with Acetals Catalyzed by Chiral Br?nsted Acids, Synlett 2016, 27, 571–574.(pdf)

　　Rui Yuan, Dan Zhao, Li-Yuan Zhang, Xiang Pan, Yan Yang, Pei Wang, Hong-Feng Li, Chao-Shan Da,Isopropylmagnesium chloride-promoted unilateral addition of Grignard reagents to β-diketones: one-pot syntheses of β-tertiary hydroxyl ketones or 3-substituted cyclic-2-enones,Org. Biomol. Chem. 2016, 14, 724-728.(pdf)

　　Pei Wang, Yan-E Jia, Jia-Zhen Zhao, Dan Zhao, Rui Yuan, Chao-Shan Da, Design and Synthesis of Chiral Binaphthol-Derived Bisphosphoric Acids and Their Application in the Catalytic Enantioselective Hydrogenation of Quinolines, Asian J. Org. Chem. 2015, 4, 430–433.（pdf）

　　Yong-Xin Yang, Yue Liu, Lei Zhang, Yan-E Jia, Pei Wang, Fang-Fang Zhuo, Xian-Tao An, and Chao-Shan Da, Aryl Bromides as Inexpensive Starting Materials in the Catalytic Enantioselective Arylation of Aryl Aldehydes: the Additive TMEDA Enhances the Enantioselectivity,    J. Org. Chem. 2014, 79, 10696-10702.(pdf)

　　Lin Sun, Qi-Peng Guo, Xiao Li, Lei Zhang, Yu-Yan Li and Chao-Shan Da, C2-Symmetric Homobimetallic Zinc Complexes as Chiral Catalysts for the Highly Enantioselective Hydrophosphonylation of Aldehydes, Asian J. Org. Chem. 2013, 2, 1031-1035. (pdf) (html)?

　　Lei Zhang, Lin Sun, Yu-Yan Li, Yue Liu, Yong-Xin Yang, Rui Yuan, Pei Wang, Chao-Shan Da, Catalytic Asymmetric Arylation of Enals to Enantioenriched Linear Trisubstituted Allylic Secondary Alcohols by using Aryl Lithiums Generated In?Situ from Aryl Bromides， ChemCatChem 2013, 5, 3516-3519. (pdf) (html)??

　　Zhi-Xue Du, Li-Yuan Zhang, Xin-Yuan Fan, Feng-Chun Wu, Chao-Shan Da, Highly Enantioselective Biomimetic Intramolecular Dehydration: Kinetic Resolution of β-Hydroxy Ketones Catalyzed by β-Turn Tetrapeptides, Tetrahedron Lett. 2013,54, 2828-2832. (pdf) (html)

　　Fang-Fang Zhuo, Wen-Wen Xie, Yong-Xin Yang, Lei Zhang, Pei Wang, Rui Yuan, Chao-Shan Da, TMEDA-Assisted Effective Direct ortho-Arylation of Electron-Deficient N-heteroarenes with Aromatic Grignard Reagents, J. Org. Chem. 2013, 78, 3243-3249. (pdf) (html)

　　Zhang, J.; Stanciu, C.; Wang, B.; Hussain, M. M.; Da, C. S.; Carroll, P. J.; Dreher, S. D.; Walsh, P. J. Palladium-Catalyzed Allylic Substitution with (η6-Arene-CH2Z)Cr(CO)3- Based Nucleophiles. J. Am. Chem. Soc. 2011, 133, 20552-20560.(pdf)(html)

　　Qin, L.; Li, L.; Yi, L.; Da, C. S.; Zhou, Y. F.  Direct Asymmetric N-Specific Reaction of Nitrosobenzene with Aldehydes Catalyzed by a Chiral Primary Amine-Based Organocatalyst, Chirality 2011, 23, 527-533.(pdf)(html)

　　Fan, X. Y.; Yang, Y. X.; Zhuo, F. F.; Yu, S. L.; Li, X.; Guo, Q. P.; Du, Z. X.; Da, C. S. AlCl3 and BDMAEE: A Pair of Potent Reactive Regulators of Aryl Grignard Reagents and Highly Catalytic Asymmetric Arylation of Aldehydes Chem. Eur. J. 2010, 16, 7988-7991. (pdf)(html) This work was highlighted by Synfacts (Yamamoto, H.; Brady, P. Synfacts 2010, 10, 1164).

　　Liu, Y.; Da, C. S.; Yu, S. L.; Yin, X. G.; Wang, J. R.; Fan, X. Y.; Li, W. P.; Wang, R. Catalytic Highly Enantioselective Alkylation of Aldehydes with Deactivated Grignard Reagents and Synthesis of Bioactive Intermediate Secondary Arylpropanols J. Org. Chem. 2010, 75, 6869 -6878.(pdf)(html)

　　Zhu, G. J.; Da, C. S.; Jia, Y. N.; Ma, X.; Yi, L. Direct Asymmetric Aldol Reaction Catalyzed by C2-symmetrical Chiral Primary Amine Organocatalysts,  Lett. Org. Chem. 2010, 7, 15-20.

　　Da, C. S.; Wang, J. R.; Yin, X. G.; Fan, X. Y.; Liu, Y.; Yu, S. L., Highly Catalytic Asymmetric Addition of Deactivated Alkyl Grignard Reagents to Aldehydes, Org. Lett. 2009, 11, 5578-5581. (pdf) (html). This work was highlighted by Synfacts (Lautens, M.; Candito, D. A. Synfacts 2010, 3, 323.) and Organic Chemistry: Highlights (Taber, D. F. Org. Chem. Highlights 2010, July 12.)

　　Wu, F. C.; Da, C. S.; Du, Z. X.; Guo, Q. P.; Li, W. P.; Yi, L.; Jia, Y. N.; Ma, X. N-Primary-Amine-Terminal β-Turn Tetrapeptides as Organocatalysts for Highly Enantioselective Aldol Reaction, J. Org. Chem. 2009, 74, 4812-4818.(pdf) (html).

　　Da, C. S.; Che, L. P.; Guo, Q. P.; Wu, F. C.; Ma, X.; Jia, Y. N.  2,4-Dinitrophenol as An Effective Cocatalyst: Greatly Improving the Activities and Enantioselectivities of Primary Amine Organocatalysts for Asymmetric Aldol Reactions, J. Org. Chem. 2009, 74, 2541-2546. (pdf) (html).

　　Ma, X.; Da, C. S.; Yi, L.; Jia, Y. N.; Guo, Q. P.; Che, L. P.; Wu, F. C.; Wang, J. R.; Li, W. P. Highly efficient primary amine organocatalysts for the direct asymmetric aldol reaction in brine, Tetrahedron: Asymmetry 2009, 20, 1419-1424.(pdf) (html)

　　Jia, Y. N.; Wu, F. C.; Ma, X.; Zhu, G. J.; Da, C. S. Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine, Tetrahedron Lett. 2009, 50, 3059-3062.(pdf) (html)

　　Yang, R. Y.; Da, C. S.; Yi, L.; Wu, F. C.; Li, H. Asymmetric conjugate addition of unmodified propionaldehyde to β-nitrostyrenes catalyzed by readily available proline-based dipeptidols, Lett. Org. Chem. 2009, 6, 44-49.

　　Li, H.; Da, C.-S.; Xiao, Y. H.; Li, X.; Su, Y. N. Direct Asymmetric Aldol Reaction of Aryl Ketones with Aryl Aldehydes Catalyzed by Chiral BINOL-Derived Zincate Catalyst, J. Org. Chem. 2008, 73, 7398-7401.(pdf) (html)

　　Da, C. S.; Ni, M.; Han, Z. J.; Yang, F.; Wang, R. Novel non-azacyclo 1,2-amino alcohols derived from phenylalanine and highly enantioselective addition of diethylzinc to aryl aldehydes, J. Mol. Catal. A: Chem. 2006, 245, 1-7.(pdf) (html)

　　Han, Z. J.; Da, C. S.; Qiu, L.; Ni, M.; Zhou, Y. F.; Wang, R. The natural amino acid derived chiral sulfonamide ligands in the catalytic asymmetric addition of phenylacetylene to aldehydes, Lett. Org. Chem. 2006, 3, 143-148.

　　Ni, M.; Wang, R.; Han, Z. J.; Mao, B.; Da, C. S.; Liu, L.; Chen, C. Synthesis of new C2-symmetrical bissulfonamide ligands and application in the enantioselective addition of alkynylzinc to aldehydes and ketones, Adv. Synth. Catal. 2005, 347, 1659-1665.(pdf)

　　Kang, Y. F.; Wang, R.; Liu, L.; Da, C. S.; Yan, W. J.; Xu, Z. Q. Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral oxazolidine ligands, Tetrahedron Lett. 2005, 46, 863-865.(pdf) (html)

　　Han, Z. J.; Da, C. S.; Xu, Z. Q.; Ni, M.; Wang, R. The asymmetric addition of phenylacetylene to aldehydes catalyzed by L-leucine derived chiral sulfonamide alcohol ligands, J. Mol. Catal. A.: Chem. 2005, 236, 32-38. (pdf) (html)

　　Da, C. S.; Xin, Z. Q.; Xiao, Y. N.; Wang, H. S.; Su, W.; Yang, F.; Wang, R. Novel β-Aminoalcohols with Bulky Substituents and the Application in Enantioselective Addition of Diethyl Zinc to Arylaldehydes(in Chinese), Chin. J. Org. Chem. 2004, 24, 943-945.(pdf)

　　Zhou, Y. F.; Wang, R.; Xu, Z. Q.; Yan, W. J.; Liu, L.; Gao, Y. F.; Da, C. S. Boc-L-proline as a new chiral ligand for enant ioselective phenylacetylene addition to aromatic aldehydes, Tetrahedron: Asymmetry 2004, 15, 589-591.(pdf) (html)

　　Xu, Z. Q.; Wang, R.; Xu, J. K.; Da, C. S.; Yan, W. J.; Chen, C. Highly enantioselective addition of phenylacetylene to aldehydes catalyzed by a β-sulfonamide alcohol-titanium complex, Angew. Chem., Int. Ed. 2003, 42, 5747-5749.(pdf) (html)

　　Wang, H. S.; Da, C. S.; Xin, Z. Q.; Su, W.; Xiao, Y. N.; Liu, D. X.; Wang, R. Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Ni(acac)2 and chiral β-amino alcohols, Chin. J. Chem. 2003, 21, 1105-1107.(pdf)

　　Da, C. S.; Han, Z. J.; Ni, M.; Yang, F.; Liu, D. X.; Zhou, Y. F.; Wang, R. A convenient synthesis of piperidine-based β-amino alcohols from L-Phe and highly enantioselective addition of diethyl zinc to aldehydes, Tetrahedron: Asymmetry 2003, 14, 659-665. (pdf) (html)

　　Da, C. S.; Wei, J.; Dong, S. L.; Xin, Z. Q.; Liu, D. X.; Xu, Z. Q.; Wang, R. Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide, Synth.Commun. 2003, 33, 2787-2792.(pdf) (html)

　　Xin, Z. Q.; Da, C. S.; Dong, S. L.; Liu, D. X.; Wei, J.; Wang, R. A novel method for the synthesis of (R)-2,2'-dihydroxy-1,1'-binaphthyl-3,3'-dicarboxylic acid by asymmetric oxidative coupling of a chiral β-naphthol derivative catalyzed by CuCl, Tetrahedron: Asymmetry 2002, 13, 1937-1940.(pdf) (html)

　　Liu, D. X.; Zhang, L. C.; Wang, Q.; Da, C.-S.; Xin, Z. Q.; Wang, R.; Choi, M. C. K.; Chan, A. S. C. The application of chiral aminonaphthols in the enantioselective addition of diethylzinc to aryl aldehydes, Org. Lett. 2001, 3, 2733-2735.(pdf) (html)

　　Yang, X. W.; Shen, J. H.; Da, C. S.; Wang, H. S.; Su, W.; Liu, D. X.; Wang, R.; Choi, M. C. K.; Chan, A. S. C. Highly enantioselective addition of diethylzinc to aldehydes catalyzed by a new chiral C2-symmetric Ti-diol complex, Tetrahedron Lett. 2001, 42, 6573-6575.(pdf) (html)

　　Liu, D. X.; Wang, Q.; Zhang, L. C.; Da, C. S.; Wang, R. Trimethylsilylcyanation of Aromatic Aldehydes Catalyzed by BINOL-Li Salt (in Chinese), Chem. J. Chin. Univ. 2001, 22, 601-602.(pdf) (html)

　　Yang, X. W.; Su, W.; Liu, D. X.; Wang, H. S.; Shen, J. H.; Da, C. S.; Wang, R.; Chan, A. S. C. Preparation and application of polymer-grafted Ti-BINOL complexes as chiral catalysts in the enantioselective addition of diethylzinc to aldehydes, Tetrahedron 2001, 56, 3511-3516.(pdf) (html)

　　Yang, X. W.; Sheng, J. H.; Da, C. S.; Wang, H. S.; Su, W.; Wang, R.; Chan, A. S. C. Polymer-Supported BINOL Ligand for the Titanium-Catalyzed Diethylzinc Addition to Aldehydes: A Remarkable Positive Influence of the Support on the Enantioselectivity of the Catalyst, J. Org. Chem. 2000, 65, 295-266.(pdf) (html).

　　Su, W.; Wang, H. S.; Da, C. S.; Wang, R. Asymmetric Synthesis of Optically Active 1,1'-Bi-2-Naphthol (in Chinese), Chem. J. Chin. Univ. 2000, 21, 1408-1409.(pdf)(html)

　　Wang, H. S.; Yang, X. W.; Su, W.; Liu, D. X.; Da, C. S.; Wang, R. Preparation of a Polymer Supported BINOL-Ti Catalyst and Its Application in Asymmetric Addition of Diethylzinc to Aldehydes (in Chinese), Chem. J. Chin. Univ. 2000, 21, 1524-1525. (pdf) (html)

　　Yang, X. W.; Shen, J. H.; Da, C. S.; Wang, R.; Choi, M. C. K.; Yang, L.; Wong, K. Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes, Tetrahedron: Asymmetry 1999, 10, 133-138.(pdf) (html)

　　二、專利申請(qǐng)

　　達(dá)朝山，謝雯雯，劉躍，一種含氮雜環(huán)芳香化合物的對(duì)稱二聚體的制備方法，申請(qǐng)?zhí)枺?01510903111.8。

　　達(dá)朝山，樊新元，卓芳芳，楊永新，不對(duì)稱催化法合成光學(xué)活性二級(jí)芳基醇，申請(qǐng)?zhí)枺篊N 201010188258，公開號(hào)： CN101844958， 2010年5月27日，專利號(hào)：ZL 2010 1 0188258.0, 授權(quán)公告日：2015年11月25日。

　　達(dá)朝山，蘇亞寧，洪滿貴，保英明，曹福軍，一種生長(zhǎng)抑素的合成方法，申請(qǐng)?zhí)枺篊N200910142420.2，公開號(hào)：CN101570570，2009年6月3日,專利號(hào)：ZL 2009 1 0142420.2，授權(quán)公告日：2013年07月10日。

　　三、參編書籍

　　達(dá)朝山，王 銳：高效手性配體的設(shè)計(jì)合成及其在二乙基鋅對(duì)醛的不對(duì)稱加成反應(yīng)中的應(yīng)用，《不對(duì)稱有機(jī)反應(yīng)》（第一版），李月明、范青華、陳新滋主編，化學(xué)工業(yè)出版社，北京，中國(guó)，2005年，第6章：pp275-291。

　　研究方向

　　1. 合成多肽作為人工酶仿生催化的化學(xué)生物學(xué)

　　2. 手性藥物的高效和綠色不對(duì)稱合成

　　3. 生物活性肽的高效合成與工藝開發(fā)

　　項(xiàng)目成果

　　國(guó)家自然科學(xué)基金項(xiàng)目：

　　格氏試劑的鈍化及其在手性配體作用下對(duì)醛的不對(duì)稱加成反應(yīng)研究，國(guó)家自然科學(xué)基金，No. 20672051，28萬元，2007年至2009年。

　　脫水酶的高級(jí)結(jié)構(gòu)肽模擬物的設(shè)計(jì)、合成及其催化β-羰基醇脫水反應(yīng)過程中的手性識(shí)別作用研究，國(guó)家自然科學(xué)基金，No. 21072087, 36萬元，2011年至2013年。

　　榮譽(yù)、獲獎(jiǎng)

　　2008年甘肅省自然科學(xué)獎(jiǎng)一等獎(jiǎng)。完成人：王銳，許兆青，達(dá)朝山，楊曉武，張邦志。項(xiàng)目名稱：具有重要醫(yī)藥用途的若干不對(duì)稱催化合成方法學(xué)研究 。（2008-Z1-002-R3）。

　　2009第十六屆“甘肅省普通高等學(xué)校青年教師成才獎(jiǎng)”。

　　社會(huì)工作

　　甘肅省化學(xué)會(huì)第十六屆理事，現(xiàn)任甘肅省化學(xué)會(huì)第十七屆理事會(huì)理事。

 

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