寧波大學(xué)海洋學(xué)院導(dǎo)師:陳海敏
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寧波大學(xué)海洋學(xué)院導(dǎo)師:陳海敏 正文
[導(dǎo)師姓名]陳海敏
[所屬院校]
寧波大學(xué)
[基本信息]
導(dǎo)師姓名:陳海敏
性別:女
人氣指數(shù):3488
所屬院校:寧波大學(xué)
所屬院系:海洋學(xué)院
職稱:研究員
導(dǎo)師類型:
招生專業(yè):海洋生物學(xué)、水產(chǎn)養(yǎng)殖、食品工程、漁業(yè)發(fā)展
研究領(lǐng)域:海洋生物生理生化、藥理(博士)
[通訊方式]
辦公電話:0574-87609572
電子郵件:chenhaimin@nbu.edu.cn
[個(gè)人簡述]
2017.7-2017.9 University of California, San Diego,Scripps Institution of Oceanography,訪問學(xué)者
2001.9-2004.8 中國科學(xué)院海洋研究所,博士
2004.8-至今 寧波大學(xué)
獲獎(jiǎng):
1. “紅藻糖生物活性研究及其產(chǎn)品開發(fā)”獲2008年度國家海洋創(chuàng)新成果獎(jiǎng)二等獎(jiǎng);
2. “基于生物活性的紅藻膳食纖維和紅藻糖的創(chuàng)新開發(fā)及其應(yīng)用”獲2009年度高等學(xué)??茖W(xué)研究優(yōu)秀成果獎(jiǎng)科學(xué)技術(shù)進(jìn)步獎(jiǎng)二等獎(jiǎng);
3. “生物活性海洋紅藻糖膠的創(chuàng)新研制和功能性產(chǎn)品開發(fā)”獲2010年度浙江省科技進(jìn)步獎(jiǎng)二等獎(jiǎng)。
4. “基于活性的紅藻膳食纖維及其深加工寡糖的產(chǎn)品技術(shù)研發(fā)”獲2008年度寧波市科技進(jìn)步獎(jiǎng)二等獎(jiǎng);
5. 2010年寧波市青年科技獎(jiǎng)
6. 151人才工程第二層次
主要研究方向:
從事海洋藥物、活性物質(zhì)、海洋生物資源利用、藻類生理等方面的研究工作。主要的研究方向?yàn)椋?br/>海洋活性天然化合物的藥理學(xué)研究(抗腫瘤、抗炎等)。
海藻的深度利用研究(藻類寡糖、多糖、蛋白、肽等的結(jié)構(gòu)、藥用保健和化妝品產(chǎn)業(yè)化開發(fā))
藻類基因組、轉(zhuǎn)基因及海藻免疫防御分子機(jī)制的研究
[科研工作]
1.Wu Wei, Zhen Zhanghe, Niu Tingting, Zhu Xiaojuan, Gao Yuli, Yan Jiangyan, Chen Yu, Yan Xiaojun, Chen Haimin. (2017). κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice. Mediators of inflammation 2017, 2017: 16. (Corresponding author).
2. Tu Shisheng, Yang Rui, Xu Xia, Chen Juanjuan, Luo Qijun, Zhu Zhujun, Chen Haimin, Yan Xiaojun. Flg22-triggered oxylipin production in Pyropia haitanensis. Phycological Research 2017, 65: 86-93. (Corresponding author).
3. Wu Wei, Wang Feng, Gao Xin, Niu Tingting, Zhu Xiaojuan, Yan Xiaojun, Chen Haimin. Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice.BMC gastroenterology2016, 16: 1. (Corresponding author).
4. Wu Wei, Wang Feng, Gao Xin, Niu Tingting, Zhen Zhanghe, Chen Haimin, Yan Xiaojun. Enhanced effect of κ-carrageenan on TNBS-induced inflammation in mice. International immunopharmacology 2016, 39: 218-228. (Corresponding author).
5.Chen Haimin, Jian Qiuli, Luo Qijun, Zhu Zhujun, Yang Rui, Yan Xiaojun. Application of oligoagars as elicitors for field aquaculture of Pyropia haitanensis.Journal of Applied Phycology 2015, 28: 1783-1791.
6.Niu Tingting, Zhang Dongsheng, Chen Haimin, Yan Xiaojun. Modulation of the binding of basic fibroblast growth factor and heparanase activity by purified λ-carrageenan oligosaccharides.Carbohydrate polymers 2015, 12: 76-84. (Corresponding author).
7.Lai Xiaojun, Yang Rui, Luo Qijun, Chen Juanjuan, Chen Haimin, Yan Xiaojun. Glycerol-3-phosphate metabolism plays a role in stress response in the red alga Pyropia haitanensis.Journal of Phycology2015, 51: 321-331. (Corresponding author).
8.Chen Haimin, Zhu Zhujun, Chen JuanJuan, Yang Rui, Luo Qijun, Xu Jilin, He Shan, Yan XiaoJun. A multifunctional lipoxygenase from Pyropia haitanensis-The cloned and functioned complex eukaryotic algae oxylipin pathway enzyme.Algal Research2015, 12: 316-327.
9.Zhu Zhujun, Qian Feijian, Yang Rui, Chen Juanjuan, Luo Qijun, Chen Haimin, Yan Xiaojun. A lipoxygenase from red alga Pyropia haitanensis, a unique enzyme catalyzing the free radical reactions of polyunsaturated fatty acids with triple ethylenic bonds.PloS one2015, 10: e0117351. (Corresponding author).
10.Chen Haimin, Wang Feng, Mao Haihua, Yan Xiaojun. Degraded λ-carrageenan activates NF-κB and AP-1 pathways in macrophages and enhances LPS-induced TNF-α secretion through AP-1.Biochimica et Biophysica Acta (BBA)-General Subjects2014, 18: 2162-2170.
11.Luo Qijun, Zhu Zhenggang, Zhu Zhujun, Yang Rui, Qian Feijian, Chen Haimin, Yan Xiaojun. Different responses to heat shock stress revealed heteromorphic adaptation strategy of Pyropia haitanensis (Bangiales, Rhodophyta).PloS one2014, 9: e94354. (Corresponding author).
12.Luo Qijun, Zhu Zhenggang, Zhu Zhujun, Yang Rui, Qian Feijian, Chen Haimin, Yan Xiaojun. Different responses to heat shock stress revealed heteromorphic adaptation strategy of Pyropia haitanensis (Bangiales, Rhodophyta).PloS one9, 4 (2014): e94354. (Corresponding author).
13.Chen Haimin, Yan Xiaojun, Wang Feng, Xu Weifeng, Zhang Lu. Assessment of the oxidative cellular toxicity of a κ-carrageenan oxidative degradation product towards Caco-2 cells.Food research international2010, 43: 2390-2401.
14. Chen Haimin, Yan Xiaojun, Lin Jing, Wang Feng, Xu Weifeng. Depolymerized products of λ-carrageenan as a potent angiogenesis inhibitor. Journal of Agricultural and Food Chemistry, 2007, 55: 6910-6917.
15. Chen Haimin, Yan Xiaojun. Antioxidant activities of agaro-oligosaccharides with different degree of polymerization in cell based system. Biochimica et Biophysica Acta. 2005, 1722: 103-111.
16. Chen Haimin, Zheng Li, Lin Wei, Yan XiaoJun. Product monitoring and quantitation of oligosaccharides composition in agar hydrolysates by precolumn labeling HPLC. Talanta,2004, 64,773-777.
國家科技部星火重大項(xiàng)目: 壇紫菜產(chǎn)業(yè)鏈升級關(guān)鍵技術(shù)集成與示范 (No. 2013GA701001)國家自然科學(xué)基金: 卡拉膠協(xié)同內(nèi)毒素引起腸道炎性損傷的分子機(jī)制研究 (No. 30800860).
國家自然科學(xué)基金“卡拉膠非安全性致炎因素及其作用方式的分子機(jī)制研究”, 2008.
浙江省自然科學(xué)基金“抗血管新生作用的λ-卡拉膠寡糖的酶法制備和構(gòu)效研究”, 2010.
發(fā)明專利:
1. 一種紅藻寡糖的制備方法. ZL200610052583.8
2. 一種λ-卡拉膠寡糖在制備血管增生的抑制劑的應(yīng)用. ZL200610052584.2
3. 一種瓊膠低聚糖在化妝品中的應(yīng)用.ZL200910099054.7
4. 一種紫菜營養(yǎng)粉的加工方法. ZL200610053928.1
5. 一種紫菜醬的加工方法. ZL200610053929.6
6. 一種瓊膠原藻生物肥及其制備方法. ZL 201110003218.9
7. 瓊膠寡糖在紫菜免疫增強(qiáng)劑中的應(yīng)用及其應(yīng)用方法. ZL201210007334.2
8. 一種促進(jìn)壇紫菜殼孢子附著萌發(fā)的方法. ZL201410698343.X
9. 一種瓊膠原藻生物肥及其制備方法. ZL201110003218.9
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