寧波大學醫(yī)學院導師：徐進

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寧波大學醫(yī)學院導師：徐進

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寧波大學醫(yī)學院導師：徐進 正文

[導師姓名]
徐進

[所屬院校]
寧波大學

[基本信息]
導師姓名：徐進
性別：男
人氣指數(shù)：2507
所屬院校：寧波大學
所屬院系：醫(yī)學院
職稱：副教授
導師類型：
招生專業(yè)：勞動衛(wèi)生與環(huán)境衛(wèi)生學
研究領域：環(huán)境毒理學



[通訊方式]
電子郵件：xujin1@nbu.edu.cn

[個人簡述]
寧波大學醫(yī)學院預防醫(yī)學系副教授，博士、博士后。2010年入選“浙江省高校優(yōu)秀青年教師資助計劃”；2011年入選浙江省“新世紀151人才工程”；2012年入選寧波市“領軍和拔尖人才培養(yǎng)工程”；2013年入選“浙江省優(yōu)秀中青年學科帶頭人”。“基于細胞應答網絡的鉛毒性效應研究”獲得2014年浙江省自然科學二等獎、2013年寧波市科技進步二等獎。主持完成國家自然科學基金、浙江省自然科學基金、中國博士后科學基金、浙江省教育廳、國家重點實驗室開放課題和寧波市自然科學基金。國家自然科學基金評審專家，浙江省自然科學基金二審專家，World Journal of Hypertension編委，PLoS One、Molecular Biology reports、Food and Chemical Toxicology等十余本SCI雜志審稿專家。在國內外核心期刊發(fā)表學術論文70余篇，SCI收錄論文35篇，單篇最高影響因子超過14。
主要研究方向：基于細胞應答反應的毒物機理研究，毒物基因組學。

[科研工作]
1. Ji LD, Li JY, Yao BB, Cai XB, Shen QJ, Xu J. Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies. Journal of human hypertension, 2017.
2. Zhou M, Feng M, Fu LL, Ji LD, Zhao JS, Xu J. Toxicogenomic analysis identifies the apoptotic pathway as the main cause of hepatotoxicity induced by tributyltin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2016, 97: 316-326.
3. Xu J, Qian HX, Hu SP, Liu LY, Zhou M, Feng M, et al. Gender-Specific Association of ATP2B1 Variants with Susceptibility to Essential Hypertension in the Han Chinese Population. BioMed research international, 2016, 2016: 1910565.
4. Tu WW, Ji LD, Qian HX, Zhou M, Zhao JS, Xu J. Tributyltin induces disruption of microfilament in HL7702 cells via MAPK-mediated hyperphosphorylation of VASP. Environmental toxicology, 2016, 31 (11): 1530-1538.
5. Ji LD, Tang NL, Xu J. AGTR1 has undergone natural selection in Euro-Asian populations in relation to ambient temperature that predisposes Chinese populations to essential hypertension. International journal of cardiology, 2016, 209: 278-280.
6. Zhou M, Tu WW, Xu J. Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells. Toxicon : official journal of the International Society on Toxinology, 2015, 101: 92-100.
7. Zeng J, Tu WW, Lazar L, Chen DN, Zhao JS, Xu J. Hyperphosphorylation of microfilament-associated proteins is involved in microcystin-LR-induced toxicity in HL7702 cells. Environmental toxicology, 2015, 30 (8): 981-988.
8. Su J, Li X, Yu Q, Liu Y, Wang Y, Song H, et al. Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients. BioMed research international, 2014, 2014: 450814.
9. Ji LD, Xu WN, Chai PF, Zheng W, Qian HX, Xu J. Polymorphisms in the CISH gene are associated with susceptibility to tuberculosis in the Chinese Han population. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2014, 28: 240-244.
10. Zheng W, Ji LD, Xing WH, Tu WW, Xu J. [Advances in genome-wide association study of tuberculosis]. Yi chuan = Hereditas, 2013, 35 (7): 823-829.
11. Zhang LN, Ji LD, Fei LJ, Yuan F, Zhang YM, Xu J. Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population. BioMed research international, 2013, 2013: 451094.
12. Xu J, Ji LD, Zhang LN, Dong CZ, Fei LJ, Hua S, et al. Lack of association between STK39 and hypertension in the Chinese population. Journal of human hypertension, 2013, 27 (5): 294-297.
13. Ji LD, Chai PF, Zhou BB, Tang NL, Xing WH, Yuan F, et al. Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population. Scandinavian journal of infectious diseases, 2013, 45 (4): 310-314.
14. Ji L, Cai X, Zhang L, Fei L, Wang L, Su J, et al. Association between polymorphisms in the renin-angiotensin-aldosterone system genes and essential hypertension in the Han Chinese population. PloS one, 2013, 8 (8): e72701.
15. Yuan F, Xu J, Ji LD, Fei LJ, Liu PP, Zhang LN. [Application of Tm-shift genotyping method in genetic studies]. Yi chuan = Hereditas, 2012, 34 (11): 1484-1490.
16. Ji LD, Qiu YQ, Xu J, Irwin DM, Tam SC, Tang NL, et al. Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations. Molecular biology and evolution, 2012, 29 (11): 3359-3370.
17. Fei LJ, Ji LD, Zhang LN, Hua S, Jin JQ, Xu J. [Application of SNPstream for medical genetics research]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2012, 29 (1): 9-12.
18. Chen DN, Zeng J, Wang F, Zheng W, Tu WW, Zhao JS, et al. Hyperphosphorylation of intermediate filament proteins is involved in microcystin-LR-induced toxicity in HL7702 cells. Toxicology letters, 2012, 214 (2): 192-199.
19. Xu J, Ji LD, Xu LH. Endoplasmic reticulum may not be involved in the lead-induced apoptosis in PC 12 cells in vitro. Environmental toxicology, 2010, 25 (1): 55-60.
20. Ji LD, Zhang LN, Shen P, Wang P, Zhang YM, Xing WH, et al. Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis. Journal of hypertension, 2010, 28 (3): 419-428.
21. Ji LD, Xu J, Wu DD, Xie SD, Tang NL, Zhang YP. Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations. Journal of pineal research, 2010, 48 (2): 133-141.
22. Xu J, Ji LD, Xu LH. Lead-induced apoptosis in PC 12 cells: involvement of p53, Bcl-2 family and caspase-3. Toxicology letters, 2006, 166 (2): 160-167.
浙江省毒理學會理事
寧波市預防醫(yī)學會理事
1. 國家自然科學基金《細胞骨架相關的微囊藻毒素毒性機理研究》2. 浙江省自然科學基金《中間纖維信號通路相關的微囊藻毒素毒性機理研究》
3. 浙江省公益技術應用研究計劃《海洋環(huán)境污染物三丁基錫的毒性機制研究》
4. 浙江省高等教育教學改革項目《構建研究型大學創(chuàng)新創(chuàng)業(yè)人才培養(yǎng)體系的探索》
5. 中國博士后科學基金《腎素-血管緊張素-醛固酮系統(tǒng)基因多態(tài)性與高血壓的關聯(lián)研究》
6. 國家重點實驗室開放課題《高血壓易感基因的分子進化研究》
7. 寧波市自然科學基金《細胞骨架相關的三丁基錫毒性機制研究》
8. 寧波市自然科學基金《腎素-血管緊張素系統(tǒng)基因多態(tài)性與原發(fā)性高血壓的關聯(lián)研究》
2014年度浙江省自然科學二等獎，《基于細胞應答網絡的鉛毒性機》，排名第一
2015年寧波市青年科技獎
2013年度寧波市科技進步獎二等獎《基于細胞應答網絡的鉛毒性效應研究》，排名第一
2011年浙江省青年教師教學技能比賽優(yōu)秀獎

[教育背景]
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