山東理工大學(xué)生命科學(xué)學(xué)院導(dǎo)師朱海亮 正文

　　朱海亮，男，教授，博士生導(dǎo)師，。
　　1965年3月出生于安徽省阜陽市。
　　zhuhl@nju.edu.cn；18913938847

　　一、簡歷
　　1988年蘭州大學(xué)化學(xué)系獲碩士學(xué)位；
　　1988-1994 年寧夏大學(xué)化學(xué)系講師；
　　1998年南京大學(xué)化學(xué)化工學(xué)院獲博士學(xué)位；
　　2000年中山大學(xué)化學(xué)與化學(xué)工程學(xué)院博士后，副研究員；
　　2000-2001德國 Philipps-University Marburg 化學(xué)系有機(jī)化學(xué)研究所二站博士后
　　2002-2011年武漢科技學(xué)院環(huán)境學(xué)院，南京大學(xué)生命科學(xué)學(xué)院，教授；
　　2011-，山東理工大學(xué)生命科學(xué)學(xué)院，南京大學(xué)生命科學(xué)學(xué)院，教授。

　　二、專業(yè)及方向：化學(xué)生物學(xué)、藥物合成化學(xué)

　　三、主持的基金項目
　　主持973子課題、863子課題、國家支撐計劃子課題、國家重大科技專項（河流主題）子課題、中央高校基本科研業(yè)務(wù)費專項資金創(chuàng)新團(tuán)隊、國家科技型中小企業(yè)技術(shù)創(chuàng)新基金、國家自然科學(xué)基金、湖北省創(chuàng)新團(tuán)隊、湖北省杰出青年基金等基金項目多項。指導(dǎo)的博士后在站期間獲得中國博士后基金項目12項。

　　四、獎勵和榮譽
　　（1）朱海亮、李環(huán)球、石磊、肖竹平、程魁、黃險峰、李玉廣、由忠錄、史大華，"市場藥物及天然活性物質(zhì)的結(jié)構(gòu)改造、結(jié)構(gòu)分析及其生物活性研究"，2008年度，教育部自然科學(xué)二等獎。
　?。?）朱海亮、陳悟、李玉廣、由忠錄，"天然活性物質(zhì)的結(jié)構(gòu)改造及其藥物活性研究"，2009年度，湖北省自然科學(xué)三等獎。
　?。?）2009-，任Curr. Med. Chem.雜志Anti-CancerAgents in Medicinal Chemistry專欄副主編。
　　（4）2008入選中國科學(xué)院"百人計劃"學(xué)者。
　?。?）2008-2011全國百篇優(yōu)秀博士論文評審專家。
　?。?）2003湖北省 "有突出貢獻(xiàn)的中青年專家"。
　　五、發(fā)表SCI收錄論文400余篇，論文被SCI刊物引用2000余次。發(fā)表的部分論文目錄如下（帶星號*的為通訊作者）。
　　1．Xiang Lu, Hui Zhang, Xi Li, Guo Chen, Qing-Shan Li, Yin Luo, Ban-Feng Ruan, Xian-Wei Chen, Hai-Liang Zhu*, Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors, Bioorg. Med. Chem., 2011, 19, 6827-6832.
　　2．Kai Liu, Hai-Liang Zhu*, Nitroimidazoles as Anti-Tumor Agents, Anti-Cancer Agent Med. Chem., 2011, 11, 687-691.
　　3．Xiao-Min Zhang, Min Qiu, Juan Sun, Yan-Bin Zhang, Yu-Shun Yang, Xiao-Liang Wang, Jian-Feng Tang, Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents, Bioorg. Med. Chem., 2011, 19, 6518–6524.
　　4．You-Yi Xia, Hai-Liang Zhu*, Polyaniline nanofiber-reinforced conducting hydrogel with unique pH-sensitivity, Soft Matter, 2011, 7, 9388-9393.
　　5．Yin Luo, Yao Li, Ke-Ming Qiu, Xiang Lu, Jie Fu, Hai-Liang Zhu*, Metronidazole acid acyl sulfonamide: A novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors, Bioorg. Med. Chem. 2011, 19, 6069-6076.
　　6．Ya-Ping Hou, Juan Sun, Zhong-Hua Pang, Peng-Cheng Lv, Dong-Dong Li, Li Yan, Hong-Jia Zhang, Emily Xi Zheng, Jing Zhao, Hai-Liang Zhu*, Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors, Bioorg. Med. Chem. 2011, 19, 5948-5954.
　　7．Zhu-Ping Xiao, Tao-Wu Ma, Mei-Lin Liao, Yu-Ting Feng, Xiao-Chun Peng, Jia-Liang Li, Zhi-Ping Li, Ying Wu, Qun Luo, Yang Deng, Xiao Liang, Hai-Liang Zhu*, Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: Synthesis, molecular docking and structureeactivity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones, Eur. J. Med. Chem., 2011, 46, 4904-4914.
　　8．Juan Sun, Yu-Shun Yang, Wei Li, Yan-Bin Zhang, Xiao-Liang Wang, Jian-Feng Tang, Hai-Liang Zhu*, Synthesis, Biological Evaluation and Molecular Docking Studies of 1,3,4-Thiadiazole Derivatives Containing 1,4-Benzodioxan as Potential Antitumor Agents, Bioorg. Med. Chem. Lett., 2011, 21, 6116-6121.
　　9．Hong-Jia Zhang, Xuan Qin, Kai Liu, Di-Di Zhu, Xiao-Ming Wang, Hai-Liang Zhu*, Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino)phenyl-N0-phenyl-thiourea, Bioorg. Med. Chem. 2011, 19, 5708-5715.
　　10．Peng-Cheng Lv, Dong-Dong Li, Qing-Shan Li, Xiang Lu, Zhu-Ping Xiao, Hai-Liang Zhu*, Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents, Bioorg. Med. Chem. Lett. 2011, 21, 5374-5377.
　　11．Juan Sun, Ning Cao, Xiao-Min Zhang, Yu-Shun Yang, Yan-Bin Zhang, Xiao-Ming Wang, Hai-Liang Zhu*, Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells, Bioorg. Med. Chem. 2011, 19, 4895-4902.
　　12．Yin Luo, Ke-Ming Qiu, Xiang Lu, Kai Liu, Jie Fu, Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents, Bioorg. Med. Chem. 2011, 19, 4730-4738.
　　13．Dong-Dong Li, Peng-Cheng Lv, Hui Zhang, Hong-Jia Zhang, Ya-Ping Hou, Kai Liu, Yong-Hao Ye, Hai-Liang Zhu*, The combination of 4-anilinoquinazoline and cinnamic acid: A novel mode of binding to the epidermal growth factor receptor tyrosine kinase, Bioorg. Med. Chem. 2011, 19, 5012-5022.
　　14．Zhen-Wei Zhu, Lei Shi, Xiao-Ming Ruan, Ying Yang, Huan-Qiu Li, Suo-Ping Xu, Hai-Liang Zhu*, Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) trrosine kinase, J. Enzym. Inhibit. Med. Chem., 2011, 26(1), 37-45.
　　15．Zi-Lin Li, Qing-Shan Li, Hong-Jia Zhang, Yang Hu, Di-Di Zhu, Hai-Liang Zhu*, Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors, Bioorg. Med. Chem. 2011, 19, 4413-4420.
　　16．Hong-Jia Zhang, Di-Di Zhu, Zi-Lin Li, Juan Sun, Hai-Liang Zhu, Synthesis, molecular modeling and biological evaluation of b-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents, Bioorg. Med. Chem. 2011, 19, 4513-4519.
　　17．Xian-Feng Huang and Hai-Liang Zhu*, Resveratrol and Its Analogues: Promising Anticancer Agents, Curr. Med. Chem.-Anti-Can. Agents, 2011, 11, 479-490.
　　18．Jie Fu, Sheng Sheng, Teng Wen, Zhi-Ming Zhang, Qing Wang, Qiu-Xiang Hu, Qing-Shan Li, Shu-Qing An, Hai-Liang Zhu*, Polycyclic aromatic hydrocarbons in surface sediments of the Jialu River, Ecotoxicology, 2011, 20, 940-950.
　　19．Zhu-Ping Xiao, Hui Ouyang, Xu-Dong Wang, Peng-Cheng Lv, Ze-Jun Huang, She-Rong Yu, Tian-Fang Yi, Ye-Ling Yang, Hai-Liang Zhu*, 4-Alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation, Bioorg. Med. Chem. 2011, 19, 3884-3891.
　　20．Xin-Hua Liu, Ban-Feng Ruan, Jing-Xin Liu, Bao-An Song, Ling-Hong Jing, Jun Li, Yang Yang, Hai-Liang Zhu* and Xing-Bao Qi, Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents, Bioorg. Med. Chem. Lett., 2011, 21, 2916-2920.
　　21．Ban-Feng Ruan, Xiang Lu, Jian-Feng Tang, Yao Wei, Xiao-Liang Wang, Yan-Bin Zhang, Li-Sheng Wang and Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents, Bioorg. Med. Chem. 2011, 19, 2688-2695.
　　22．Jie Fu, Yan-Hua Ding, Luo Li, Sheng Sheng, Teng Wen, Lu-Ji Yu, Wu Chen, Shu-Qing An* and Hai-Liang Zhu*, Polycyclic aromatic hydrocarbons and ecotoxicological characterization of sediments from the Huaihe River, China, J. Environ. Monit., 2011, 13, 597-604.
　　23．Zhu-Ping Xiao, Xing-Bing He, Zhij-Yun Peng, tao-Ju Xiong, Juan Peng, Li-Hua Chen and Hai-Liang Zhu*, Synthesis, structure, molecular docking, and structure–activity relationship analysis of enamines: 3-Aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials, Bioorg. Med. Chem. 2011, 19, 1571-1579.
　　24．Z.-P. Xiao, Z.-Y. Peng, M.-J. Peng, W.-B. Yan, Y.-Z. Ouyang and Hai-Liang Zhu*, Flavonoids Health Benefits and Their Molecular Mechanism, Mini-Rev. Med. Chem., 2011, 11, 169-177.
　　25．Ban-Feng Ruan, Yu-Peng Tian, Ren-Tao Hu, Hong-Ping Zhou, Jie-Ying Wu, Jia-Xiang Yang and Hai-Liang Zhu*, Synthesis, crystal structures and in vitro antibacterial activity of two novel organotin(IV) complexes, Inorg. Chim. Acta, 2011, 365, 473-479.
　　26．Ban-Feng Ruan, Yu-Peng Tian, Hong-Ping Zhou, JieYing Wu, Ren-Tao Hu, Chen-Hao Zhu, Jia-Xiang Yang and Hai-Liang Zhu*, Synthesis, characterization and in vitro antitumor activity of three organotin(IV) complexes with carbazole ligand, Inorg. Chim. Acta, 2011, 365, 302-308.
　　27．Lei Shi, Zi-Lin Li, Ying Yang, Zhen-Wei Zhu, Hai-Liang Zhu*, Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors, Bioorg. Med. Chem. Lett., 2011, 21, 121-124.
　　28．Peng-Cheng Lv, Tian-Tian Cai, Yong Qian, Juan Sun, Hai-Liang Zhu*, Synthesis, biological evaluation of chrysin derivatives as potential immunosuppressive agents, Eur. J. Med. Chem., 2011, 46, 393-398.
　　29．Peng-Cheng Lv, Jing Xiong, Jin Chen, Kai-Rui Wang, Wen-Jun Mao and Hai-Liang Zhu*, Novel depsides as potential anti-inflammatory agents with potent inhibitory activity against Escherichia coli-induced interleukin-8 production, J. Enzym. Inhibit. Med. Chem., 2010, 25(4), 590-595.
　　30．Yong-Ming Cui, Wen-xuan Yan, Ying-Jie Cai, Wu Chen and Hai-Liang Zhu*, Synthesis, molecular docking, and inhibitory activity of a Ni Schiff-base complex against urease, J. Coord. Chem., 2010, 63(21), 3706-3713.
　　31．Jie Fu, Ying Yang, Xue-Wei Zhang, Wen-Jun Mao, Zhi-Ming Zhang, Hai-Liang Zhu*, Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase, Bioorg. Med. Chem. 2010, 18, 8457–8462.
　　32．Yong Qian, Hong-Jia Zhang, Peng-Cheng Lv, Hai-Liang Zhu*, Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents, Bioorg. Med. Chem. 2010, 18, 8218-8225.
　　33．Qing-Zhong Zheng, Xiao-Min Zhang, Ying Xu, Kui Cheng, Qing-Cai Jiao, Hai-Liang Zhu*, Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents, Bioorg. Med. Chem. 2010, 18, 7836-7841.
　　34．Ying Yang, Lei Shi, Yang Zhou, Huan-Qiu Li, Zhen-Wei Zhu, Hai-Liang Zhu*, Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors, Bioorg. Med. Chem. Lett. 2010, 20, 6653-6656.
　　35．Zhu-Ping Xiao*, Tao-Wu Ma, Wei-Chang Fu, Xiao-Chun Peng, Ai-Hua Zhang, Hai-Liang Zhu*, The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors, Eur. J. Med. Chem., 2010, 45, 5064-5070.
　　36．Huan-Qiu Li, Peng-Cheng Lv, Lei Shi and Hai-Liang Zhu*, Structure-based Discovery of Novel Antibacterials, Curr. Med. Chem.- Anti-Infective Agents, 2010, 9, 168-179.
　　37．Ban-Feng Ruan, Ten-Tao Hu, Yu-Peng Tian*, Jie-Ying Wu, Hai-Liang Zhu*, Synthesis, characterization, and biological activity of a Cu(I) complex with 2-(9H-carbazol-9-yl) acetic acid, J. Coord. Chem. 2010, 63(17), 2999-3005.
　　38．Suo-Ping Xu, Lei Shi, Yuan Pei, Ying Yang, Hai-Liang Zhu*, Synthesis and antibacterial activities of copper(II) with, [(2-hydroxy-3,5-diiodo-benzylidene)-amino]-acetic acid, J. Coord. Chem. 2010, 63(19), 3463-3470.
　　39．Xin-Hua Liu, Hui-Feng Liu, Jin Chen, Yang Yang, Bao-An Song, Lin-Shan Bai, Jing-Xin Liu, Hai-Liang Zhu*, Xing-Bao Qi, Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents, Bioorg. Med. Chem. Lett. 2010, 20, 5705-5708.
　　40．Wu Chen, Yuguang Li, Yongming Cui, Xian Zhang, Hai-Liang Zhu*, Qingfu Zeng*, Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors, Eur. J. Med. Chem., 2010, 45, 4473-4478.
　　41．Suo-Ping Xu, Hai-Liang Zhu*, Synthesis and antimicrobial activities of metal(II) complexes with 2,4-diiodo-6-phenyliminomethyl-phenol, J. Coord. Chem. 2010, 63(18), 3291-3300.
　42．Lei Shi, Rui-Qin Fang, Zhen-Wei Zhu, Ying Yang, Kui Cheng, Wei-Qing Zhong, Hai-Liang Zhu*, Design and synthesis of potent inhibitors of b-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents, Eur. J. Med. Chem., 2010, 45, 4358-4364.
　　43．Peng-Cheng Lv, Juan Sun, Yin Luo, Ying Yang, Hai-Liang Zhu*, Design, synthesis, and structure–activity relationships of pyrazole derivatives as potential FabH inhibitors, Bioorg. Med. Chem. Lett. 2010, 20, 4657-4660.
　　44．Yong Qian, Hong-Jia Zhang, Hao Zhang, Chen Xu, Jing Zhao, Hai-Liang Zhu*, Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents, Bioorg. Med. Chem. 2010, 18, 4991-4996.
　　45．Huan-Qiu Li, Yin Luo, Ran Song, Zi-Lin Li, Tao Yan, Hai-Liang Zhu*, Design, Synthesis, and Immunosuppressive Activity of New Deoxybenzoin Derivatives, ChemMedChem, 2010, 5(7), 1117-1122.
　　46．Yin Luo, Huan-Qiu Li, Yang Zhou, Zi-Lin Li, Hai-Liang Zhu*, Metronidazole-Deoxybenzoin Derivatives as Anti-Helicobacter pylori Agents with Potent Inhibitory Activity against HPE Induced Interleukin-8, ChemMedChem, 2010, 5(7), 1110-1116.
　　47．Yong Qian, Gao-Yuan Ma, A Lv, Hai-Liang Zhu, Jing Zhao and VH Rawal, Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines, Chem. Commun., 2010, 46(17), 3004-6.
　　48．Xin-Hua Liu, Hui-Feng Liu, Xu Shen, Bao-An Song, Pinaki S. Bhadury, Hai-Liang Zhu*, Jin-Xing Liu, Xing-Bao Qi, Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents, Bioorg. Med. Chem. Lett., 2010, 20, 4163-4167.
　　49．Peng-Cheng Lv, Huan-Qiu Li, Juan Sun, Yang Zhou, Hai-Liang Zhu*, Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents, Bioorg. Med. Chem. 2010, 18, 4606-4614.
　　50．Yong Qian, Gao-Yuan Ma, Ying Yang, Kui Cheng, Qing-Zhong Zheng, Wen-Jun Mao, Lei Shi, Jing Zhao*, Hai-Liang Zhu*, Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents, Bioorg. Med. Chem. 2010, 18, 4310-4316.
　　51．Jie Fu, Teng Wen, Qing Wang, Xue-Wei Zhang, Qing-Fu Zeng*, Shu-Qing An* and Hai-Liang Zhu*, Degradation of Active Brilliant Red X-3B by a microwave discharge electrodeless lamp in the presence of activated carbon, Environ. Technol., 2010, 31(7), 771-779.
　　52．Qing-Zhong Zheng, Kui Cheng, Xiao-Min Zhang, Kai Liu, Qing-Cai Jiao*, Hai-Liang Zhu*, Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents, Eur. J. Med. Chem., 2010, 45, 3207-3212.
　　53．Yong-Miao Shen, Peng-Cheng Lv, Wu Chen, Peng-Gang Liu, Ming-Zhu Zhang, Hai-Liang Zhu*, Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line, Eur. J. Med. Chem., 2010, 45, 3184-3190.
　　54．Jie Fu, Kui Cheng, Zhi-Ming Zhang, Rui-Qin Fang, Hai-Liang Zhu*, Synthesis, structure and structure–activity relationship analysis of caffeic acid amides as potential antimicrobials, Eur. J. Med. Chem., 2010, 45, 2638-2643.
　　55．Kui Cheng, Qing-Zhong Zheng, Jin Hou, Yang Zhou, Chang-Hong Liu*, Jing Zhao*, Hai-Liang Zhu*, Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics, Bioorg. Med. Chem. 2010, 18, 2447-2455.
　　56．Huan-Qiu Li, Yin Luo, Peng-Cheng Lv, Lei Shi, Chang-Hong Liu *, Hai-Liang Zhu*, Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents, Bioorg. Med. Chem. Lett. 2010, 20, 2025-2028.
　　57．Lei Shi, Ying Yang, Zi-Lin Li, Zhen-Wei Zhu, Chang-Hong Liu*, Hai-Liang Zhu*, Design of novel nicotinamides as potent and selective monoamine oxidase inhibitors, Bioorg. Med. Chem. 2010, 18, 1659-1664.
　　58．Peng-Cheng Lv, Kai-Rui Wang, Qing-Shan Li, Jin Chen, Juan Sun, Hai-Liang Zhu*, Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents, Bioorg. Med. Chem. 2010, 18, 1117-1123.
　　59．Qing-Zhong Zheng, Fei Zhang, Kui Cheng, Ying Yang, Yu Chen, Yong Qian, Hong-Juan Zhang, Huan-Qiu Li, Chang-Fang Zhou, Shu-Qing An*, Qing-Cai Jiao*, Hai-Liang Zhu*, Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents, Bioorg. Med. Chem. 2010, 18, 880-886.
　　60．Peng-Cheng Lv, Chang-Fang Zhou, Jin Chen, Peng-Gang Liu, Kai-Rui Wang, Wen-Jun Mao, Huan-Qiu Li, Ying Yang, Jing Xiong, Hai-Liang Zhu*, Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorg. Med. Chem. 2010, 18, 314-319.
　　61．Huan-Qiu Li, Tao Yan, Ying Yang, Lei Shi, Chang-Fang Zhou*, Hai-Liang Zhu*, Synthesis and structure–activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N0-phenylureas and thioureas as antitumor agents. Bioorg. Med. Chem. 2010, 18, 305-313.

　　六、部分發(fā)明專利

　　1、 朱海亮、李冬冬、王曉亮、李靜然、孫建、杜茜如、方飛，4-苯胺喹唑啉類和取代肉桂酸的復(fù)合物及其制備方法與用途，申請?zhí)枺?01110315166.9
　　2、 朱海亮、孫娟、張雁濱、楊雨順、王曉亮、張飛，一類噻唑琳酮衍生物及其制法，申請?zhí)枺?01110308986.5
　　3、 朱海亮、王曉亮、張雁濱、楊雨順、湯劍鋒、張飛，香草酸酰腙類衍生物及其制備和用途，申請?zhí)枺?01110309009.7
　　4、 朱海亮、胡楊、張雁濱、王曉亮、楊雨順，1,3,4-噁二唑類化合物的制備及其在抗癌治療藥物中的應(yīng)用，申請?zhí)枺?01110308980.8
　　5、 朱海亮、駱銀、裘科明。肉桂?；酋０奉惢衔锏闹苽浼捌湓诳拱┲委熤械膽?yīng)用。申請?zhí)枺?01110170735.5。
　　6、 朱海亮、付杰、張雪薇、楊先輝、張莉蓉、劉常宏、張平、宋雙。新型藻類隔開培養(yǎng)裝置。申請?zhí)枺?011050900142460。
　　7、 朱海亮、張志明、張雪薇、燕茹。2,5-二取代-1,3,4-噁二唑衍生物及其制法與用途。申請?zhí)枺?01110087058.0。
　　8、 朱海亮、付杰、楊先輝、張雪薇、張莉蓉、何禎祥。光皮樹油在減肥藥物開發(fā)中的應(yīng)用，申請?zhí)?01110063909.8。
　　9、 朱海亮、張曉敏、孫娟、劉凱、楊雨順、燕茹、張雁濱，含1,4-苯并二噁烷的1,3,4-噁二唑衍生物的制法及其在抗癌藥物中應(yīng)用，申請?zhí)?01110073034.X
　　10、 朱海亮、付杰、張莉蓉、張雪薇、楊先輝、何禎祥，光皮樹油在降血脂藥物中的應(yīng)用，申請?zhí)?01110063909.8。
　　11、 朱海亮、孫娟、楊雨順、張曉敏、章虹佳、劉凱、李子琳 秦旋,含1,4-苯并二噁烷的噻二唑衍生物及其制法與其抗菌活性，申請?zhí)?01110063740.6。
　　12、 朱海亮、章虹佳、祝迪迪、孫娟、李子琳，塞克硝唑肉桂酸酯衍生物的合成及其在抗菌藥物方面的應(yīng)用，申請?zhí)?01110063758.6。
　　13、 朱海亮、鄭慶忠、張曉敏、董凱、焦慶才。2-氯吡啶衍生物及其制法與在制備抗肝癌藥物中的應(yīng)用，申請?zhí)枺?01010244869.2，公開號：CN 101914095A。
　　14、 朱海亮、鄭慶忠、劉凱、董凱、焦慶才。1,3,4-噁二唑衍生物及其制法與在制備抗腫瘤藥物中的應(yīng)用，申請?zhí)枺?01010240482.X，公開號：CN 101914094A。
　　15、 朱海亮、付杰、張志明。苯并三唑衍生物及其制法與用途，申請?zhí)?201010222902.1，申請日：2010.07.09，公開日：2010.12.29，公開號CN 101928254A。
　　16、 朱海亮、呂鵬程、王開銳、陳進(jìn)。一類含有吡唑環(huán)的硫脲類衍生物及其制法和用途，申請?zhí)枺?00910263121.4，公開號：CN 101735150
　　17、 朱海亮、駱銀、李環(huán)球。苯并三唑衍生物及其制法與用途，申請?zhí)?01010222902.1
　　18、 朱海亮、駱銀、李環(huán)球。一種肟類化合物及其制備方法與用途，申請?zhí)?00910233389.3
　　19、 朱海亮、鄭慶忠、程魁、焦慶才。苯甲酸氮芥衍生物及其制備方法與用途，申請?zhí)?00910036290.4
　　20、 朱海亮、呂鵬程、王開銳、陳進(jìn)、毛文君。一類白楊素和取代水楊酸酯復(fù)合物及其制法和用途，申請?zhí)枺?01010111304.7，公開號：CN 101768147
　　21、 朱海亮、王開銳、呂鵬程。白楊素長鏈衍生物及其制備方法與用途，申請?zhí)枺?01010111246.8，公開號：CN 101774994A
　　22、 朱海亮、肖竹平、錢勇。3-芳基喹啉類化合物及其制法和用途，申請?zhí)枺?01010111249.1，公開號：CN 101759635
　　23、 朱海亮、呂鵬程、阮班鋒、孫娟、陳進(jìn)。一類含有吡唑環(huán)的噻唑類衍生物及其制法和用途，申請?zhí)枺?00910264116.5，公開號：CN 101759695，授權(quán)號ZL200910264116.5。
　　24、 朱海亮、呂鵬程、王開銳、陳進(jìn)。一類含有吡唑環(huán)的硫脲類衍生物及其制法和用途，申請?zhí)枺?00910263221.4.
　　25、 朱海亮、李青山、李環(huán)球、嚴(yán)濤、駱銀。一類尿素衍生物及其制法與用途，申請?zhí)枺?00910262954.9，公開號：CN 101735113.
　　26、 朱海亮，祝禎偉，石磊，楊瑩 水楊酰苯胺類衍生物及其制法與用途。專利申請?zhí)?00910233731.X
　　27、 朱海亮、楊瑩、石磊、祝禎偉。N-喹啉酰胺類衍生物及其制法與用途，申請?zhí)枺?00910232198.5，公開號：CN101723894.
　　28、 朱海亮、呂鵬程。一類新型白楊素和取代水楊酸酯復(fù)合物及其制法和用途，申請?zhí)枺?00910184606.4.
　　29、 朱海亮、毛文君、呂鵬程。甲硝唑和取代水楊酸的復(fù)合物及其制法與用途，申請?zhí)枺?00910027775.7. 公開號CN 101560189A；授權(quán)號ZL200910027775.7.
　　30、 朱海亮、李環(huán)球、嚴(yán)濤。一類硫脲類衍生物及其制備方法與用途，申請?zhí)枺?00910031329.3. 公開號CN 101560175A
　　31、 朱海亮，宋忠誠，馬高遠(yuǎn)，呂鵬程，石磊。一類新型N-叔丁基化噻唑烷酸類化合物及其制法和用途. 申請?zhí)枺?00810234101.X。公開號：CN101407502。授權(quán)號：ZL 2008 10234101.X。
　　32、 朱海亮，呂鵬程，宋忠誠。一類新型縮酚酸類化合物及其制法和用途。申請?zhí)枺?00810020994.8。公開號：CN101333166。
　　33、 朱海亮、石磊、宋忠誠，1,4-丁二磺酸鈉的制備方法，申請?zhí)?007101918947，公開號CN 101219976A，授權(quán)號ZL200710191894.7.
　　34、 朱海亮，李環(huán)球，石磊，曹平，尿素類衍生物及其制備方法與用途，申請?zhí)?00710190629.7，公開號CN101161645A，授權(quán)號ZL200710190629.7.
　　35、 朱海亮，肖竹平，張麗娜，徐 琛，喹啉類鳶尾黃素電子等排體及其制法和用途，申請?zhí)?2006101613662，公開號 CN100999492A，授權(quán)號ZL200610161366.2.
 

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