山東大學(xué)生命科學(xué)學(xué)院導(dǎo)師：苗俊英 正文

　　苗俊英 教授
　　博士生導(dǎo)師
　　電話:0531-88364929
　　E-mail:miaojy@sdu.edu.cn
　　
　　基本情況
　　苗俊英，女，出生年月：1957.11.07,博士，教授，2001被聘為博導(dǎo)，中國生物醫(yī)學(xué)工程學(xué)會(huì)理事，中華醫(yī)學(xué)會(huì)醫(yī)學(xué)工程學(xué)分會(huì)干細(xì)胞工程專業(yè)委員會(huì)委員。
　　
　　學(xué)習(xí)和工作經(jīng)歷
　　1983年畢業(yè)于武漢大學(xué)生物系，獲得細(xì)胞生物學(xué)學(xué)士學(xué)位；
　　1986年畢業(yè)于武漢大學(xué)研究生院，獲得細(xì)胞生物學(xué)碩士學(xué)位。
　　1986年9月開始在山東大學(xué)生物系細(xì)胞生物學(xué)教研室工作。
　　1992年10月赴日本名古屋大學(xué)理學(xué)部留學(xué)，
　　1997年9月獲得該大學(xué)理學(xué)博士學(xué)位。
　　1998年3月回山東大學(xué)生命科學(xué)學(xué)院工作。
　　1999年9月被聘為山東大學(xué)生命科學(xué)學(xué)院教授。
　　2001年9月被聘為山東大學(xué)生命科學(xué)學(xué)院博士生導(dǎo)師。
　　2004年7月-12月，日本山口大學(xué)醫(yī)學(xué)部，進(jìn)行血管生理學(xué)合作研究。
　　2007年7月-10月，香港中文大學(xué)聯(lián)合院基礎(chǔ)醫(yī)學(xué)部孔祥復(fù)院士實(shí)驗(yàn)室，進(jìn)行化學(xué)蛋白組學(xué)的合作研究。
　　
　　研究方向
　　學(xué)科專業(yè)：細(xì)胞生物學(xué)；研究方向： 細(xì)胞分化與轉(zhuǎn)分化
　　主要研究內(nèi)容：1.血管內(nèi)皮細(xì)胞增殖、分化、老化及凋亡和轉(zhuǎn)分化的分子機(jī)制研究；2.血管生成的分子機(jī)制研究； 3.神經(jīng)干細(xì)胞和骨髓基質(zhì)干細(xì)胞分化與凋亡機(jī)理研究；4.利用化學(xué)小分子研究細(xì)胞分化與凋亡的分子機(jī)制。
　　
　　承擔(dān)課題
　　1. 利用化學(xué)小分子研究血管內(nèi)皮凋亡與自噬性死亡關(guān)聯(lián)的分子機(jī)制(90813022), 國家自然科學(xué)基金重大研究計(jì)劃資助項(xiàng)目. 2009.01-2011.12。
　　2. 磷脂酰膽堿特異性磷酯酶C在血管內(nèi)皮細(xì)胞自噬中的作用及機(jī)理研究(31070735), 國家自然科學(xué)基金面上項(xiàng)目，2011.01-2013.12。
　　3. 化學(xué)小分子在骨髓間充質(zhì)干細(xì)胞分化、老化和凋亡控制中的應(yīng)用,山東大學(xué)交叉學(xué)科創(chuàng)新基金，2010-2012。
　　4．動(dòng)脈粥樣硬化發(fā)病機(jī)制及其診治與干預(yù)的基礎(chǔ)研究，動(dòng)脈粥樣硬化斑塊不穩(wěn)定性和早期防治，973項(xiàng)目分課題（2011CB503906）。2011-2015。
　　5. 心血管重構(gòu)分子機(jī)制和干預(yù)策略研究，國家自然科學(xué)基金創(chuàng)新研究群體（81021001），2011-2013。
　　
　　研究成果及發(fā)表論文
　　發(fā)表論文（SCI）：
　　1.Lu Zhang, Jing Zhao, Le Su, Bin Huang, Li Wang, Hua Su, Yun Zhang, ShangLi Zhang, JunYing Miao*. D609 inhibits progression of preexisting atheroma and promotes lesion stability in apoE-/- mice: a role of PC-PLC in atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):411-8. Epub 2010 Feb 5. (IF=7.235).
　　2.Li Wang, ZhiWu Dong, Bin Huang, BaoXiang Zhao, Hua Wang, Jing Zhao,, HsiangFu Kung, ShangLi Zhang, JunYing Miao*. Distinct Patterns of Autophagy Evoked by Two Benzoxazine Derivatives in Vascular Endothelial Cells. Autophagy, 2010 (IF=6.829). DOI: 10.4161/auto.6.8.13508
　　3.Le Su, HongLing Zhao, ChunHui Sun, BaoXiang Zhao*, Jing Zhao, ShangLi Zhang, Hua Su, JunYing Miao*. The role of Hmbox1 in endothelial differentiation of bone-marrow stromal cells by a small molecule. ACS Chemical Biology, 2010 (IF=5.108). DOI: 10.1021/cb100153r
　　4.ZhiWu Dong, YiZhe Cheng, Jing Zhao, Le Su, BaoXiang Zhao, Yun Zhang, ShangLi Zhang, JunYing Miao* Discovery of a benzoxazine derivative promoting angiogenesis in vitro and in vivo. J Cell Physiol. 2010 Apr;223(1):202-8. (IF=4.586). 本論文2010年7月1日獲Faculty of 1000 Biology推薦和點(diǎn)評(píng)
　　5.Meng N, Wu L, Gao J, Zhao J, Su L, Su H, Zhang S, Miao J*. Lipopolysaccharide induces autophagy through BIRC2 in human umbilical vein endothelial cells. J Cell Physiol. 2010 Oct;225(1):174-9. (IF=4.586)
　　6.Sun C, Liu X, Qi L, Xu J, Zhao J, Zhang Y, Zhang S, Miao J*. Modulation of vascular endothelial cell senescence by integrin beta4. J Cell Physiol. 2010 May 27. [Epub ahead of print]. (IF=4.586)
　　7.Le Su, Xin Lv, JiPing Xu, DeLing Yin, HaiYan Zhang, Yi Li, Jing Zhao, ShangLi Zhang, JunYing Miao*. Neural stem cell differentiation mediated by integrin β4 in vitro. Int J Biochem Cell Biol. 2009 Apr;41(4):916-924. (IF=4.887).
　　8.Nan Wang, Chunhui Sun, Siwei Huo, Yun Zhang, Jing Zhao, Shangli Zhang, Junying Miao*. Cooperation of phosphatidylcholine-specific phospholipase C and basic fibroblast growth factor in the neural differentiation of mesenchymal stem cells in vitro. Int J Biochem Cell Biol. 2008;40(2):294-306. (IF=4.178)
　　9.Xin Lv, Le Su, Deling Yin, Chunhui Sun, Jing Zhao, Shangli Zhang, Junying Miao*. Knockdown of integrin β4 in primary cultured mouse neurons blocks survival and induces apoptosis by elevating NADPH oxidase activity and ROS level. Int J Biochem Cell Biol. 2008；40（4）:689-699. Oct 11; (IF=4.178).
　　10.Le Su, Jing Zhao, Baoxiang Zhao, Junying Miao*, Deling Yin, Shangli Zhang. Safrole oxide induced vascular endothelial cell differentiation into neuron-like cells by depressing the reactive oxygen species level at the low concentration. Biochimica et Biophysica Acta. 2006 Feb;1763(2):247-53.(IF=6.9).
　　11.Zhao J, Miao J*, Zhao B, Zhang S, Yin D. Suppressing Akt phosphorylation and activating Fas by safrole oxide inhibited angiogenesis and induced vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 and serum. Int J Biochem Cell Biol. 2006, 38(9): 1603-13. (IJBCB) (IF=4.8).
　　12.Huang B, Meng N, Zhao B*, Zhao J, Zhang Y, Zhang S, Miao J*. Protective Effects of a Synthesized Butyrolactone Derivative against Chloroquine-Induced Autophagic Vesicle Accumulation and the Disturbance of Mitochondrial Membrane Potential and Na(+),K(+)-ATPase Activity in Vascular Endothelial Cells. Chem. Res. Toxicol. 2009, 22, 471–475 (IF=3.74)
　　13.Chuandong Fan, Jing Zhao, Baoxiang Zhao, Shangli Zhang, Junying Miao*. A novel complex of copper and a salicylaldehyde pyrazole hydrazone derivative induces apoptosis through up-regulating integrin β4 in vascular endothelial cells. Chem. Res. Toxicol. 2009, 22, 1517–1525 (IF=3.74).
　　14.Xia Liu, Deling Yin, Yun Zhang, Jing Zhao, Shangli Zhang, Junying Miao*. Vascular endothelial cell senescence mediated by integrin β4 in vitro. FEBS Lett. 2007 Nov 27;581(28):5337-42. (IF=3.4).
　　15.Yizhe Cheng, Qitao Zhao, Xia Liu, Satohiko Araki, Shangli Zhang, Junying Miao*. Phosphatidylcholine-specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells. FEBS Lett. 2006 Sep 4;580(20):4911-5. (IF=3.4).
　　16.ChunHui Sun, Nan Wang, Jie Huang, Jie Xin, Fen Peng, YinShi Ren, ShangLi Zhang, JunYing Miao*. Inhibition of phosphatidylcholine-specific phospholipase C prevents bone marrow stromal cell senescence in vitro. J Cell Biochem. 2009 Jul 22;108(2):519-528 (IF=2.935)
　　17.Xia Liu, Jing Zhao, JiPing Xu, BaoXiang Zhao, Yun Zhang, ShangLi Zhang and JunYing Miao*. Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin β4, ROS, NF-kB and P53 in vascular endothelial cells. Bioorg Med Chem Lett. 2009 May 15;19(10):2896-900. (IF=2.5).
　　18.ZhiWu Dong, Li Wang, JiPing Xu, YuLian Li, Yun Zhang, ShangLi Zhang, JunYing Miao*. Promotion of autophagy and inhibition of apoptosis by low concentrations of cadmium in vascular endothelial cells. Toxicol In Vitro. 2009 Feb;23(1):105-110. (IF=2.5).
　　19.Jing Zhao, Qiuxia He, Bin Huang, Baoxiang Zhao*, Hua Su, Shangli Zhang and Junying Miao *. A benzoxazine derivative induced vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 by elevating NADPH oxidase activity and reactive oxygen species levels. Toxicol In Vitro. 2009. 23 (2009) 1039–1046 (IF=2.5).
　　20.Song Lian, Hua Su, Bao-Xiang Zhao*, Wei-Yong Liu, Liang-Wen Zheng, Jun-Ying Miao*. Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells. Bioorg. Med. Chem. 17, 2009, 7085-7092.（IF=2.8）
　　21.Zheng Liang-Wen, Wu Ling-Ling, Zhao Bao-Xiang*, Dong Wen-Liang, Miao Jun-Ying*. Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells. Bioorg. Med. Chem. 17, 2009, 1957-1962. （IF=2.8）
　　22.Xiao-Ling Ding, Hai-Yan Zhang, Lei Qi, Bao-Xiang Zhao*, Song Lian, Hong-Shui Lv, Jun-Ying Miao*. Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells. Bioorg. Med. Chem. Letters 19, 2009,5325-5328. （IF=2.65）
　　23.Wei-Yong Liu, Hai-Ying Li, Bao-Xiang Zhao*, Dong-Soo Shin, Song Lian, Jun-Ying Miao*. Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells. Carbohydrate Research 344 (2009) 1270–1275.
　　24.Ning Meng, Jing Zhao, BaoXiang Zhao, Yizhe Cheng, Weiwei Wang, Yun Zhang, ShangLi Zhang, JunYing Miao*. A novel butyrolactone derivative inhibited smooth muscle cell migration and proliferation and maintained endothelial cell functions through selectively affecting Na, K-ATPase activity and mitochondria membrane potential during in vitro angiogenesis. J Cell Biochem. 2008 Aug 15;104(6):2123-30. J Cell Biochem. 2008 Aug 15;104(6):2123-30. (IF=3.5).
　　25.Qiuxia He, Bin Huang, Jing Zhao, Yun Zhang, Shangli Zhang, Junying Miao*. Knockdown of integrin β4-induced autophagic cell death associated with P53 in A549 lung adenocarcinoma cells. FEBS J. 2008 Nov;275(22):5725-32. (IF=3.1).
　　26.Zhang L, Zhu X, Zhao B, Zhao J, Zhang Y, Zhang S, Miao J*. A novel isochroman derivative inhibited apoptosis in vascular endothelial cells through depressing the levels of integrin beta4, p53 and ROS. Vascul Pharmacol. 2008 February - March;48(2-3):63-69. （IF=2.367）.
　　27.Zhang Y, Woodruff M, Zhang Y, Miao J, Hanley G, Stuart C, Zeng X, Prabhakar S, Moorman J, Zhao B, Yin D. Toll-like receptor 4 mediates chronic restraint stress -induced immune suppression. J Neuroimmunol. 2008 Feb;194(1-2):115-22. J Neuroimmunol. 2008 Feb;194(1-2):115-22.
　　28.Yi Zhang, Ying Zhang , Junying Miao, Gregory Hanley, Charles Stuart, Xiuli Sun, Tingting Chen, and Deling Yin. Chronic Restraint Stress Promotes Immune Suppression through Toll-like Receptor 4-Mediated Phosphoinositide 3-kinase Signaling. J Neuroimmunol. 2008 Nov 15;204(1-2):13-9.
　　29.Le Su, Xin Lv, JunYing Miao *. Integrin β4 in neural cells. Neuromolecular Med. 2008;10(4):316-21. (IF=3.4).
　　30.Chuan-Dong Fan, Bao-Xiang Zhao*, Fang Wei, Gai-Hua Zhang, Wen-Liang Dong, Jun-Ying Miao*. Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2’-hydroxy-3’-aroxypropyl)-3-aryl-1 H -pyrazole-5-carbohydrazide derivatives. Bioorganic & Medicinal Chemistry Letters. 18(2008):3860-3864. (IF=2.6).
　　31.Jin-Hua Zhang, Chuan-Dong Fan, Bao-Xiang Zhao*, Dong-Soo Shin, Wen-Liang Dong, Yong-Sheng Xie, Jun-Ying Miao*. Synthesis and preliminary biological eva luation of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells. Bioorg. Med. Chem. 16，2008，10165. (IF=3.075)
　　32.Xiao-Hong Pan, Xia Liu, Bao-Xiang Zhao*, Yong-Sheng Xie, Dong-Soo Shin, Shang-Li Zhang, Jing Zhao, Jun-Ying Miao*. 5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis. Bioorg Med Chem. 2008 Oct 15;16(20):9093-100. (IF=3.075).
　　33.Zhao BX, Zhang L, Zhu XS, Wan MS, Zhao J, Zhang Y, Zhang SL, Miao JY*. Synthesis and discovery of a novel pyrazole derivative as an inhibitor of apoptosis through modulating integrin beta4, ROS, and p53 levels in vascular endothelial cells. Bioorg Med Chem. 2008 May 1;16(9):5171-80. (IF=3.075).
　　34.Xia Y, Fan CD, Zhao BX*, Zhao J, Shin DS, Miao JY*. Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells. Eur J Med Chem. 2008 Nov;43(11):2347-2353. (IF=2.187).
　　35.Yong-Sheng Xie, Xiao-Hong Pan, Bao-Xiang Zhao, Jin-Ting Liu, Dong-Soo Shin, Jin-Hua Zhang, Liang-Wen Zheng, Jing Zhao, Jun-Ying Miao*. Synthesis, structure characterization and preliminary biological eva luation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives. Journal of Organometallic Chemistry 693 (2008) 1367–1374. (IF=2.33).
　　36.Kikushima E, Nakamura S, Oshima Y, Shibuya T, Miao JY, Hayashi H, Nikai T, Araki S. Hemorrhagic activity of the vascular apoptosis-inducing proteins VAP1 and VAP2 from Crotalus atrox. Toxicon. 2008 Sep 15;52(4):589-93.(IF=2.246).
　　37.Xia Y, Dong ZW, Zhao BX*, Ge X, Meng N, Shin DS, Miao JY*. Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells. Bioorg Med Chem. 2007 Nov 15;15(22):6893-6899. (IF=2.6).

　　38.Nan Wang, Kun Xie, Siwei Huo, Jing Zhao, Shangli Zhang, Junying Miao*. Suppressing Phosphatidylcholine-specific Phospholipase C and elevating ROS level, NADPH oxidase activity and Rb level induced neuronal differentiation in mesenchymal stem cells. J Cell Biochem. 2007 Apr 15; 100(6):1548-57. (IF=3.5).
　　39.Zhao J, Zhao BX, Wang WW, Huang B, Zhang SL, Miao JY*. Phosphatidylcholine-specific phospholipase C and ROS were involved in chicken blastodisc differentiation to vascular endothelial cells. J Cell Biochem. 2007 Oct 1;102(2):421-8. (IF=3.5).
　　40.Le Su, BaoXiang Zhao*, Xin Lv, Jing Zhao, ShangLi Zhang and JunYing Miao*. Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3167-71. (IF=2.5).
　　41.Qiuxia He, Xingshang Zhu, Mei Shi, Baoxiang Zhao*, Jing Zhao, Shangli Zhang, Junying Miao*. Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells. Bioorg Med Chem. 2007 Jun 1;15(11):3889-95. (IF=2.6).
　　42.Wang WW, Liu X, Zhao J, Zhao BX, Zhang SL, Miao JY*. A novel butyrolactone derivative inhibited apoptosis and depressed integrin β4 expression in vascular endothelial cells. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):482-5. (IF=2.5).
　　43.Le Su, BaoXiang Zhao*, Xin Lv, Nan Wang, Jing Zhao, ShangLi Zhang, JunYing Miao*. Depressing integrin beta4 level and SOD activity and elevating ROS level and NADPH oxidase activity induced apoptosis in neurons by Safrole oxide. Life Sciences. 2007 Feb 20; 80(11):999-1006 (IF=2.5).
　　44.Weiwei Wang, Xia Liu, Yun Zhang, Jing Zhao, Baoxiang Zhao*, Shangli Zhang, Junying Miao*. Both senescence and apoptosis induced by deprivation of growth factors were inhibited by a novel butyrolactone derivative through depressing integrinβ4 in vascular endothelial cells. Endothelium. 2007 Nov-Dec;14(6):325-32. (IF=2.3).
　　45.Masuda S, Maeda H, Miao JY, Hayashi H, Araki S. cDNA Cloning and Some Additional Peptide Characterization of a Single-Chain Vascular Apoptosis-Inducing Protein, VAP2. Endothelium. 2007 Mar-Apr;14(2):89-96. (IF=2.3).
　　46.Xia Liu, Qitao Zhao, Satohiko Araki, Shangli Zhang, Junying Miao*. Contrasting Effects of Phosphatidylinosital- and Phosphatidylcholine-Specific Phospholipase C on Apoptosis in Cultured Endothelial Cells. Endothelium, 2006 May-Jun;13(3):205-11. (IF=2.3).
　　47.Nan Wang; Xin Lv; Le Su; BaoXiang Zhao; ShangLi Zhang, JunYing Miao*. D609 blocks cell survival and induces apoptosis in neural stem cells. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4780-3. (IF=2.5).
　　48.Du A, Zhao B, Yin D, Zhang S, Miao J*. Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells. Bioorg Med Chem Lett. 2006 Jan 1;16(1):81-3. (IF=2.5).
　　49.Du A, Zhao B, Yin D, Zhang S, Miao J*. Safrole Oxide Induces Apoptosis by Up-regulating Fas and FasL instead of Integrin beta4 in A549 Human Lung Cancer Cells. Bioorg Med Chem. 2006 Apr 1;14(7):2438-45. (IF=2.6).
　　50.Xin Lv, Nan Wang, Le Su, Shangli Zhang, and Junying Miao*. Inhibition of PC-PLC blocked the survival of mouse neural cells by up-regulating the expression of integrin beta4 and Rb. Developmental Neuroscience. 2006, 28: 499-504. (IF=2.6).
　　51.Chuandong Fan, Weiwei Wang, Baoxiang Zhao*, Shangli Zhang, Junying Miao*. Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells. Bioorg Med Chem. 2006 May 1;14(9):3218-22. (IF=2.6).
　　52.Wei F, Zhao BX, Huang B, Zhang L, Sun CH, Dong WL, Shin DS, Miao JY*. Design, synthesis, and preliminary biological eva luation of novel ethyl 1-(2'-hydroxy-3'-aroxypropyl)-3-aryl-1H-pyrazole-5-carboxylate. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6342-6347. (IF=2.6). 本論文2007年被評(píng)為中國百篇最具影響的國際學(xué)術(shù)論文。
　　53.Jiao PF, Zhao BX*, Wang WW, He QX, Wan MS, Shin DS, Miao JY*. Design, synthesis, and preliminary biological eva luation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2862-2867. (IF=2.6).
　　54.Yin D, Woodruff M, Zhang Y, Whaley S, Miao J, Ferslew K, Zhao J, Stuart C. Morphine promotes Jurkat cell apoptosis through pro-apoptotic FADD/P53 and anti-apoptotic PI3K/Akt/NF-kappaB pathways. J Neuroimmunol. 2006, 174(1-2): 101-107. (IF=2.88).
　　55.Zhao J, Miao J*, Zhao B, Zhang S. Upregulating of Fas, integrin beta4 and P53 and depressing of PC-PLC activity and ROS level in VEC apoptosis by safrole oxide. FEBS Lett. 2005 Oct 24;579(25):5809-13. (IF=3.42).
　　56.Zhao J, Miao J*, Zhao B, Zhang S, Yin D. Safrole oxide inhibits angiogenesis by inducing apoptosis. Vascul Pharmacol. 2005 Jun;43(1):69-74.. (IF=1.2).
　　57.Maruyama J, Hayashi H, Miao J, Sawada H, Araki S. Severe cell fragmentation in the endothelial cell apoptosis induced by snake apoptosis toxin VAP1 is an apoptotic characteristic controlled by caspases. Toxicon. 2005, 46(1): 1-6. (IF=2.26).
　　58.Du AY, Zhao BX, Yin DL, Zhang SL, Miao JY*. Discovery of a novel small molecule, 1-ethoxy-3-(3, 4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cells. Bioorg Med Chem. 2005 Jul 1;13(13):4176-83.. (IF=2.29).
　　59.Qitao Zhao, Satohiko Araki, ShangLi Zhang, Junying Miao*. Rattlesnake venom induces apoptosis by stimulating PC-PLC and upregulating the expression of integrin b4, P53 in vascular endothelial cells. Toxicon, 44 (2004) 161–168. (SCI，IF=1.862).
　　60.Qitao Zhao, Nan Wang, Ru Jia, Shangli Zhang, Junying Miao*. Integrin β4 is a Target of Rattlesnake Venom during Inducing Apoptosis of Vascular Endothelial Cells, Vascular Pharmacology, 41, (2004) 1-6. (SCI，IF=2.547).
　　61.Zhao KW, Zhao QT, Zhang SL, Miao JY*, Integrin beta4 mAb inhibited apoptosis induced by deprivation of growth factors in vascular endothelial cells, Acta Pharmacol Sin. 2004 Jun; 25 (6): 733-7. (SCI，IF=1.125).
　　62.Nan Wang，Chun-qing Du, Shao-shan Wang, Kun Xie, Shang-li Zhang, Jun-ying Miao*. D609 induces vascular endothelial cells and marrow stromal cells differentiation into neuron-like cells，Acta Pharmacologica Sinica，2004, 25（4）：442－446（SCI，IF=1.125）.
　　63.Aiying Du, Baoxiang Zhao*, Shangli Zhang, Junying Miao*. Safrole Oxide Induces Apoptosis in A549 Human Lung Cancer Cells. Experimental Lung Research. 2004, 30：1－11. （SCI，IF=1.464）.
　　64.Jing Zhao, Baoxiang Zhao, Aiying Du, Qitao Zhao, and Junying Miao*. Effects of Novel Safrole Oxide Derivatives, 1-Propyl-3-(3,4-methylenedioxyphenyl)-2-propanol and Isopropoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, on Apoptosis Induced by Deprivation of Survival Factors in Vascular Endothelial Cells. Endothelium, 2004, 11（5）: 267-273. (SCI，IF=2.017).
　　65.Chunqing Du, Qitao Zhao, Satohiko Araki, Shangli Zhang and Junying Miao*. Apoptosis mediated by phosphatidylcholine-specific phospholipase C is associated with cAMP, p53 level and cell cycle distribution in vascular endothelial cells. Endothelium, 2003，10(3): 141-147.
　　66.Zhao Bao-Xiang, DU Ai-Ying, Miao Jun-Ying*, ZHAO Ke-Wen, DU Chun-Qing. Effects of novel safroleoxide derivatives, 1-Methoxy-3-(3,4-methylenedioxy-benzyl)-2-propanol and 1-ethoxy-3-(3,4-methylenedioxybenzyl)-2-propanol, on apoptosis induced by deprivation of survival factors in vascular endothelial cells. Vascular Pharmacology, 2003, 40（3）：182-187.
　　67.Satohiko Araki, Shinako Masuda, Hiroki Maeda, Miao jun-Ying, Hiroshi Hayashi. Involvement of specific integrins in apoptosis induced by vascular apoptosis-inducing protein I. Toxicon. 2002 May;40(5):535-42.
　　68.Miao J-Y*, Zhao B-X, Li H-H, Zhang S-L, Du C-Q. Effect of safrole oxide on vascular endothelial cell growth and apoptosis induced by deprivation of fibroblast growth factor. Acta Pharmacol Sin 2002 Apr: 23(4): 323-326.
　　69.Miao JY*, Araki S, Zhang SL, Hayashi H. 1-Methyl-3-isobutylxanthine delays apoptosis Induced by deprivation of growth factors in vascular endothelial cells. Acta Pharmacological Sinica 2000, 21(10): 936-938.
　　70.Miao Jun-Ying*，Zhang Shang-Li, Hayashi H.Expression of bcl-2 gene increases in apoptosis of vascular endothelial cells induced by rattlesnake venom. Chinese Science Bulletin. 2000, 45 (13): 1195-1198.
　　71.Miao JY*, Araki S, Zhang HW, Hayashi H. Effect of manoalide on apoptosis induced by deprivation of survival factors in vascular endothelial cells. Acta Pharmacological Sinica, 1999, 20(2): 121-125.
　　72.Miao JY*, Araki S, Han YR, Hayashi H. Involvement of gene expression in apoptosis of vascular endothelial cells induced by rattlesnake venom. Cell Research, 1999, 9 (3): 237-242.
　　73.Miao JY, Kaji K, Hayashi H, Araki S. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J. Biochem., 1997, 121: 612-618.
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　　授權(quán)的國家發(fā)明專利
　　1．發(fā)明名稱：黃樟素氧化物在血管內(nèi)皮細(xì)胞生長與凋亡中的應(yīng)用
　　發(fā)明人：苗俊英，趙寶祥，張尚立，杜春青。
　　專利號(hào)：ZL 02 1 10135.3
　　授權(quán)公告日：2004年9月1日
　　2. 發(fā)明名稱：利用三環(huán)葵烷-9-基-二硫代碳酸酯鉀鹽誘導(dǎo)骨髓基質(zhì)細(xì)胞向神經(jīng)元分化的方法。
　　發(fā)明人：苗俊英，張尚立，王楠
　　專利號(hào)： ZL 2004 1 0023497.5
　　授權(quán)公告日：2005年5月18日
　　3.發(fā)明名稱: 利用三環(huán)葵烷-9-基-二硫代碳酸酯鉀鹽誘導(dǎo)血管內(nèi)皮細(xì)胞向神經(jīng)元分化的方法
　　發(fā)明人：苗俊英，張尚立，王楠
　　專利號(hào)：ZL 200410023498.x
　　授權(quán)公告日：2005年5月18日
　　4. 發(fā)明名稱: 3-芐基-5-(2-硝基苯氧甲基)-γ-丁內(nèi)酯的制藥用途
　　發(fā)明人：苗俊英，趙寶祥，張尚立，王瑋瑋，張 璐
　　專利號(hào)：ZL 2006 1 0043244.3
　　授權(quán)公告日：2008年5月14日
　　5. 發(fā)明名稱: 黃樟素氧化物在內(nèi)皮細(xì)胞與神經(jīng)干細(xì)胞培養(yǎng)體系中的應(yīng)用
　　發(fā)明人：苗俊英，趙寶祥，張尚立，蘇 樂
　　專利號(hào)：ZL 2006 1 0070567.1
　　授權(quán)公告日：2008年12月24日
　　6. 3-芐基-5-(2-硝基苯氧甲基)-γ-丁內(nèi)酯的應(yīng)用
　　發(fā)明人：苗俊英，趙寶祥，張尚立，趙靜，盟寧
　　專利號(hào)： ZL 2007 10016184.0
　　授權(quán)公告日：2010年05月19日
　　7. 2，3-二氫-3-羥甲基-6-氨基-[1,4]-苯并噁嗪在制備藥物中的應(yīng)用
　　發(fā)明人：苗俊英，趙寶祥，張尚立，趙靜，孫春輝
　　專利號(hào)： ZL 2007 10113257.8
　　授權(quán)公告日：2010年08月11日

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