上海中醫(yī)藥大學基礎醫(yī)學院導師：駱嘉 正文

[導師姓名]
駱嘉

[所屬院校]
上海中醫(yī)藥大學

[基本信息]
導師姓名：駱嘉
性別：男
人氣指數(shù)：1869
所屬院校：上海中醫(yī)藥大學
所屬院系：基礎醫(yī)學院
職稱：教授
導師類型：博導
招生專業(yè)：中西醫(yī)結(jié)合基礎
研究領域：（1）酒精暴露在發(fā)育過程中導致胎兒酒精譜系障礙（FASD）和嚴重的中樞神經(jīng)系統(tǒng)損害。在闡明...

[通訊方式]


[個人簡述]
1)Liu D, Ke Z, Luo J.Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy.Mol Neurobiol. 2016 Sep 5. [Epub ahead of print] Review.
2)Wang Y, Xu M, Ke ZJ, Luo J.Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer.Pharmacol Res. 2017 Jan;115:299-308.
3)Wang X, Xu M, Frank JA, Ke ZJ, Luo J.Thiamine deficiency induces endoplasmic reticulum stress and oxidative stress in human neurons derived from induced pluripotent stem cells.Toxicol Appl Pharmacol. 2017 Apr 1;320:26-31
4)Ren Z, Yang F, Wang X, Wang Y, Xu M, Frank JA, Ke ZJ, Zhang Z, Shi X, Luo J.Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation. Toxicol Appl Pharmacol. 2016 Oct 1;508:11-19.
5)Ren Z, Wang X, Xu M, Yang F, Frank JA, Ke ZJ,Luo J. Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas. Oncotarget. 2016 Aug 5;7(34):54303-316.
6)Xu M, Ren Z, Wang X, Comer A, Frank JA, Ke ZJ, Huang Y, Zhang Z, Shi X, Wang S, Luo J. ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis. Mol Cancer. 2016 Jul 14;15(1):52.
7)Xu M, Wang S, Ren Z, Frank JA, Yang XH, Zhang Z, Shi X, Luo J (2016)Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38 gamma. Oncotarget7(3):3489-505.
8)Xu M, Wang S, Wang H, Qi Y, Chen L, Frank JA, Yang X, Zhang Z, Shi X, Luo J (2016). Role of MCP-1 in alcohol-induced aggressiveness of colon cancer cells. Mol Carcinog 55(5):1002-11
9)Son YO, Pratheeshkumar P, Roy RV, Hitron JA, Wang L, Divya SP, Xu M,Luo J, Chen G, Zhang Z, Shi X (2015) Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis. J Biol Chem. 290(45):27090-100.
10)Wang F, Yu K, Yang JJ, Lu YM, Xu YZ, Chen l, Fang H, Wang X, Hu Z, Kan L, Luo J*, Wang S(2015)Activation of NF-κB pathway mediates alcohol-enhanced progression and metastasis of human hepatocellular carcinoma. Mol Cancer14(1):10
11)Wang H, Wang X, Ke ZJ, Ashley LC, Xu M, Frank JA, Zhang Z, Shi X., Luo J (2015). Tunicamycin-induced unfolded protein response in the developing moues brain. Toxicol Appl Pharmacol.283(3):157-167
12)Johnson S., Hussain SA., Duncan J., Chen G., Luo J., Mclaurin C., Rajkowska G., Ou XM., Stockmeier CA. and Wang J (2015) Alcohol exposure increases double-stranded RNA activated protein kinase (PKR) in the human and rat prefrontal cortex. Alcohol. Clin. Exp Res 39(3):476-84
13)Yong Y., Meng Y., Ding H., Fan Z., Tang Y., Zhou C., Luo J*., Ke ZJ (2015) RAX regulates the migration of cerebellar granule neurons in the developing cerebellum. Sci Rep5:7961
14)Yu K., Yang J., Wang F., Chen L., Luo Y., Luo J., Wang S. (2014). Ethanol Supports Macrophage Recruitment and Reinforces Invasion and Migration of Lewis Lung Carcinoma. Alcohol. Clin. Exp Res38(10):2597-606
15)Ji Z., Fan Z., Yu R., Yang H., Zhang Y., Luo J*., Ke ZJ (2014) Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2. J. Immunol 193(5):2157-67
16)Baldwin LA, Hoff JT, Lefringhouse J, Zhang M, Jia C, Liu Z, Erfani S, Jin H, Xu M, She QB, van Nagell JR, Wang C, Chen L, Plattner R, Kaetzel DM,Luo J, Lu M, West D, Liu C, Ueland FR, Drapkin R, Zhou BP, Yang XH. (2014) CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling.Oncotarget. 5(23):12203-17.
17)Lu Y., Ni F., Xu M., Yang J., Chen J., Chen Z., Wang X., Luo J*. Wang S (2014) Alcohol promotes mammary tumor growth through activation of VEGF-dependent tumor angiogenesis. Oncol Lett8:673-678
18)Wang H, Ke ZJ, Alimov A, Xu M, Frank JA, Fang S, Luo J (2014). Spatiotemporal expression of MANF in the developing rat brain. PLoS One9(2):e90433
19)Chen Z, Ballar P, Fu Y,Luo J, Du S, Fang S (2014) The E3 Ubiquitin Ligase gp78 Protects against ER Stress in Zebrafish Liver.J Genet Genomics. 41(7):357-68
20)Liu M, Alimov A, Wang H, Frank JA, Katz W, Xu M, Ke ZJ,Luo J (2014). Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK. Neuroscience267:102-113
21)Udemgba C, Johnson S, Stockmeier C, Luo J, Albert PR, Wang J, May WL, Harris S, Sittman DB, Ou XM (2014) The Expression of KLF11 (TIEG2), a MAO B-transcriptional activator in the prefrontal cortex of human alcohol dependence. Alcohol. Clin. Exp Res38(1):144-51
22)Wang H, Bower KA, Frank JA, Xu M, Luo J(2013) Hypoxic preconditioning alleviates ethanol neurotoxicity: the involvement of autophagy. Neurotox Res. 24(4):472-7
23)Alimov A, Wang H, Liu M, Frank JA, Xu M, Luo J (2013). Expression of autophagy and UPR genes in the developing brain during ethanol-sensitive and resistant Periods. Metabolic Brain Disease 28(4):667-76
24)Li W, Tang Y, Fan Z, Meng Y, Yang G, Luo J*, Ke ZJ. (2013) Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide. Mol Neurodegener.8:27
25)Meng Y, Yong Y, Yang G, Ding H, Fan Z, Tang Y, Luo J*, Ke ZJ (2013) Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism. J. Neurochem. 126(6):805-18.

[科研工作]
2015/01-至今上海中醫(yī)藥大學教授
2008/12-至今美國肯塔基大學醫(yī)學院終身教授
2005/07-2008/11 西弗吉尼亞大學終身副教授
2003/08-2014/04中科院上海生科院客座研究員
2001/02-2008/12 美國國家職業(yè)安全與健康研究所客座研究員
1999/11-2005/06 西弗吉尼亞大學助理教授
1998/07-1999/11 愛荷華大學研究助理教授
1995/01-1998/06 愛荷華大學博士后
1989/08-1995/01 愛荷華大學助教/研究助理
1984/09-1989/07福建師范大學講師
序號課題名稱研究起止時間經(jīng)費數(shù)(萬元)

[教育背景]
1980/09-1984/07 中國海洋大學，生物學學士
1989/08-1995/01 美國愛荷華大學，細胞生物學博士 以上老師的信息來源于學校網(wǎng)站，如有更新或錯誤，請聯(lián)系我們進行更新或刪除，聯(lián)系方式

上海中醫(yī)藥大學

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