沈陽藥科大學藥學院導師：尹然 正文

[導師姓名]
尹然

[所屬院校]
沈陽藥科大學

[基本信息]
導師姓名：尹然
性別：女
人氣指數(shù)：1481
所屬院校：沈陽藥科大學
所屬院系：藥學院
職稱：副教授
導師類型：碩導
招生專業(yè)：藥物分析學、藥學（藥物分析學方向）
研究領域：研究方向一：基于系統(tǒng)生物學方法開展中藥藥效物質基礎和作用機制研究研究方向二：中藥質量控制方...

[通訊方式]
辦公電話：024-43520595
電子郵件：yinran100@126.com
通訊地址：遼寧省本溪高新技術產(chǎn)業(yè)開發(fā)區(qū)華佗大街26號

[個人簡述]
尹然，女，博士，副教授。2003年畢業(yè)于沈陽藥科大學，獲藥學(日語)專業(yè)理學學士學位，同年考取沈陽藥科大學藥物分析專業(yè)研究生，2005年獲得碩博連讀資格，2008年獲藥物分析學博士學位，畢業(yè)后留校任教。2012年被聘為沈陽藥科大學副教授，現(xiàn)為藥物分析專業(yè)碩士生導師。研究方向：中藥質量控制方法、藥效物質基礎與作用機制研究，藥品質量標準制定，藥代動力學研究等。作為課題負責人主持了國家自然科學基金青年基金項目1項，遼寧省自然科學基金項目1項，遼寧省教育廳項目1項，沈陽藥科大學中青年骨干人才培育計劃項目1項；另外，作為項目主要成員參與承擔國家自然科學基金項目，國家科技重大專項子課題，省、市各級科研項目共15項。目前已在國內(nèi)外學術期刊和學術會議上發(fā)表研究論文36篇，其中SCI收錄23篇，獲遼寧省自然科學學術成果獎（學術論文類）1項；沈陽市自然科學學術成果獎（學術論文類）2項。

[科研工作]
近年來發(fā)表代表性論文(限第一作者或通訊作者，SCI須寫明影響因子)：1.Fei Han, Yanting Li, Li Ma, Tianfeng Liu, Yawen Wu, Rui Xu, Aihua Song, Ran Yin*. A rapid and sensitive UHPLC-FT-ICR MS/MS method for identification of chemical constituents in Rhodiola crenulata extract, rat plasma and rat brain after oral administration. Talanta. 2016, 160:183-193. (IF=4.035)2.Fei Han, Yan-ting Li, Xin-juan Mao, Xiao-shu Zhang, Jiao Guan, Ai-hua Song*, Ran Yin*. Metabolic profile of salidroside in rats using high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Analytical and Bioanalytical Chemistry. 2016, 408 (7)：1975-1981. (IF=3.125)3.Fei Han, Yanting Li, Xinjuan Mao, Rui Xu，Ran Yin*. Characterization of chemical constituents in Rhodiola Crenulate by high-performance liquid chromatography coupled with Fourier-transform ion cyclotron resonance mass spectrometer (HPLC-FT-ICR MS). J Mass Spectrom. 2016, 51:363-368. (IF=2.541)4.Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guan, Xiaoshu Zhang, Xinjuan Mao, Longshan Zhao, Qing Li, Xiaohong Hou, Ran Yin*. Identification of the absorbed components and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma by ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. J Pharm Biomed Anal. 2015, 111:277-287. (IF=2.979)5.Ke-Lin Chen, Kai-Shun Bi, Fei Han, He-Yun Zhu, Xiao-Shu Zhang, Xin-Juan Mao, Ran Yin*. Evaluation of the protective effect of Zhi-Zi-da-Huang decoction on acute liver injury with cholestasis induced by α-naphthylisothiocyanate in rats. J Ethnopharmacol. 2015, 172:402-409. (IF=2.998)6.Zheng Tang, Ran Yin*, Kaishun Bi, Heyun Zhu, Fei Han, Kelin Chen, Fenrong Wang. Simultaneous quantitative determination of 20 active components in the traditional Chinese medicine formula Zhi-Zi-Da-Huang decoction by liquid chromatography coupled with mass spectrometry: application to study the chemical composition variations in different combinations. Biomed Chromatogr. 2015, 29 (9): 1406-1414. (IF=1.723)7.Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guan, Zheng Tang, Kelin Chen, Longshan Zhao, Qing Li, Ran Yin*, Xiaohong Hou*. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: Application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. J Chromatogr B. 2014, 960:116-125. (IF=2.694)8.Heyun Zhu, Ran Yin*, Fei Han, Jiao Guan, Xiaoshu Zhang, Xinjuan Mao, Longshan Zhao, Qing Li, Xiaohong Hou, Kaishun Bi*. Characterization of chemical constituents in Zhi-Zi-Da-Huang decoction by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Sep Sci. 2014, 37 (23):3489-3496. (IF=2.594)9.Ran Yin, Fei Han, Zheng Tang, Ran Liu, Xu Zhao, Xiaohui Chen, Kaishun Bi*. UFLC–MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. J Pharm Biomed Anal. 2013, 72:127-133. (IF=2.947)10.Ran Yin, Xin-Xiu Deng, Fei Han, Zhen Song, Wei-Ming Cheng, Xiao-Hui Chen, Kai-Shun Bi*. Determination of five components in Ixeris sonchifolia by high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2007, 43 (4): 1364-1369. (IF=2.761)

[教育背景]

沈陽藥科大學

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