廈門大學(xué)生物學(xué)系導(dǎo)師:余嫻文

發(fā)布時(shí)間:2021-10-09 編輯:考研派小莉 推薦訪問(wèn):
廈門大學(xué)生物學(xué)系導(dǎo)師:余嫻文

廈門大學(xué)生物學(xué)系導(dǎo)師:余嫻文內(nèi)容如下,更多考研資訊請(qǐng)關(guān)注我們網(wǎng)站的更新!敬請(qǐng)收藏本站,或下載我們的考研派APP和考研派微信公眾號(hào)(里面有非常多的免費(fèi)考研資源可以領(lǐng)取,有各種考研問(wèn)題,也可直接加我們網(wǎng)站上的研究生學(xué)姐微信,全程免費(fèi)答疑,助各位考研一臂之力,爭(zhēng)取早日考上理想中的研究生院校。)

廈門大學(xué)生物學(xué)系導(dǎo)師:余嫻文 正文

  
  姓名:余嫻文  
  性別:女  
  職稱:副教授
  所獲學(xué)位:博士
  授予單位:新加坡國(guó)立大學(xué) 
  學(xué)院:生命科學(xué)學(xué)院
  研究方向:纖毛發(fā)育,結(jié)構(gòu),及其功能的分子機(jī)制
  學(xué)科專長(zhǎng):斑馬魚胚胎發(fā)育的遺傳調(diào)控
  聯(lián)系電話:2182609
  E-MAIL:yuxw@xmu.edu.cn
  通信地址:廈門大學(xué)生物II館322A
  郵編:361005
    
  個(gè)人簡(jiǎn)歷:
  學(xué)士: 1990-1994, 廈門大學(xué)生物學(xué)系微生物學(xué)專業(yè)
  博士: 1999-2005, 新加坡國(guó)立大學(xué)分子與細(xì)胞生物學(xué)研究院
  博士后: 2005-2010, 新加坡科技研究局分子與細(xì)胞生物學(xué)研究院
  1994, B.Sc., Xiamen University; 2005, Ph.D., Institute of Molecular and Cell Biology, National University of Singapore; 2005-2010, Research Fellow at the Institute of Molecular and Cell Biology, Agency of Science, Technology and Research (A*STAR) , Singapore; 2010-present, Associate Professor, School of Life Sciences, Xiamen University.

  主要研究方向 (Research areas):
  
越來(lái)越多的研究表明纖毛(Cilia),這一在生物進(jìn)化過(guò)程中非常保守且分布廣泛的細(xì)胞器,在細(xì)胞運(yùn)動(dòng)和信號(hào)傳導(dǎo)過(guò)程中行使著重要的功能。纖毛在結(jié)構(gòu)和功能上的異常會(huì)導(dǎo)致多種器官的疾病,統(tǒng)稱為“纖毛相關(guān)疾病”。本人以斑馬魚(Zebrafish)為模式動(dòng)物,深入研究調(diào)控纖毛發(fā)育,結(jié)構(gòu),及其功能的分子機(jī)制。這些研究將有助于更深入地理解人類“纖毛相關(guān)疾病”的發(fā)病機(jī)理,為“纖毛相關(guān)疾病”的診斷和治療提供理論依據(jù)。
  Cilia are evolutionarily conserved, microtubule-based cellular organelles in eukaryotes. With the increasing number of genetic diseases associated with ciliary dysfunctions identified over years, it becomes essentially important to study the ciliogenic program to elucidate the mechanisms of these ciliopathies. Currently, we are using zebrafish as a model system to further investigate the molecular mechanisms in the regulations of ciliogenesis. Our studies aim to provide the further understandings about the clinical features of ciliary dysfunctions.

  Selected Publications:
  
Yu X., Lau D., Ng C. P., Roy S. Cilia driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear. Development 138: 487-494, 2011.
  Tay S. Y., Yu X., Wong K. N., Panse P., Ng C. P., Roy S. The Iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Developmental Dynamics 239:527-34, 2010.
  Yu X., Ng C. P., Habacher H., and Roy S. Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nature Genetics 40: 1445-1453, 2008.
  Qiu W, Neo SP, Yu X, Cai M. A novel septin-associated protein, Syp1p, is required for normal cell cycle-dependent septin cytoskeleton dynamics in yeast. Genetics. Nov;180(3):1445-57,2008
  Xu, J., Srinivas, B. P., Tay, S. Y., Mak, A., Yu, X., Lee, S. G. P., Yang, H., Govindarajan, K. R., Leong, B., Bourque, G., Mathavan, S., and Roy, S. Genome-wide expression profiling in the zebrafish embryo indentifies target genes regulated by Hedgehog signalling during vertebrate development. Genetics 174, 735-752, 2006
  Yu X., Cai M. The yeast dynamin-related GTPase Vps1p functions in the organization of the actin cytoskeleton via interaction with Sla1p. J Cell Sci. 117, 3839-53, 2004
  Zeng G, Yu X, Cai M. Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p. Mol Biol Cell. 12, 3759-72, 2001.

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