姓名：范明性別：男職稱：研究員、教授招生院所：基礎(chǔ)醫(yī)學(xué)院招生類型：科學(xué)學(xué)位(博)科學(xué)學(xué)位(碩)招生專業(yè)：神經(jīng)生物學(xué)(博)神經(jīng)生物學(xué)(碩)研究方向名稱：低氧等環(huán)境因素對神經(jīng)肌肉發(fā)育與損傷修復(fù)的作用與機制電子信箱：fanmingchina@126.com

社會任職

1.全國應(yīng)用生理專業(yè)委員會主任委員

2.亞太地區(qū)高原醫(yī)學(xué)會常務(wù)理事

3.中國神經(jīng)科學(xué)會常務(wù)理事

個人簡歷

1.197610-198007:北京第二醫(yī)學(xué)院醫(yī)療四系學(xué)生

2.198009-198307:軍事醫(yī)學(xué)科學(xué)院碩士

3.198509-198807:軍事醫(yī)學(xué)科學(xué)院博士

4.1989-1993:軍事醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所副研究員

5.1993-:軍事醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所研究員

6.2006-:首都醫(yī)科大學(xué)客座教授

重要學(xué)術(shù)論文

1.DingXF,ZhaoYQ,FanWH,WuLY,HuangX,WangF,HeYL,LiuSH,WuY,ZhaoT,WuY,ZhuLL,FanM..Genetransferintothebothsidesofpostnatalcerebralcortexusingtweezerelectrode.CNSNeurosciTher..2013,19(3):197-8..SCI

2.WangY,YangJ,LiH,WangX,ZhuL,FanM,WangX..HypoxiapromotesdopaminergicdifferentiationofmesenchymalstemcellsandshowsbenefitsfortransplantationinaratmodelofParkinson'sdisease..PLoSOne..2013,8(1):e54296.SCI

3.XiongL,WangF,HuangX,LiuZH,ZhaoT,WuLY,WuK,DingX,LiuS,WuY,ZhaoY,ZhuLL,FanM.DNAdemethylationregulatestheexpressionofmiR-210inneuralprogenitorcellssubjectedtohypoxia.FEBSJ..2012,279(23):4318-26.SCI

4.DingXF,ZhaoYQ,HuZY,LinK,WangF,LiuSH,WuY,WuLY,ZhaoT,HuangX,WuY,ZhuLL,FanWH,FanM.Efficientgenetransferintoneonatalmousebrainusingelectroporation.NeurochemRes..2012,37(7):1392-8..SCI

5.1.XinHuang,JiaSun,TongZhao,KuiwuWu,KazutadaWatanabe,Zhi-ChengXiao,LinglingZhu,MingFan.LossofNB-3aggravatescerebralischemiabyimpairingneuronsurvivalandneuritegrowth..Stroke.2012,42:2910-2916.SCI

6.2.XiangLi,XuWang,PengZhang,LinglingZhu,TongZhao,ShuhongLiu,YanWu,XiaopingChen,MingFan..Extracellularsignal-regulatedkinase1/2mitogen-activatedproteinkinasepathwayisinvolvedininhibitionofmyogenicdifferentiationofmyoblastsbyhypoxia.ExpPhysiol,.2011,061382:1-8.SCI

7.ZhuLL,ZhaoT,huangX,FanM.Geneexpressionprofilesandmetabolicchangesinembryonicneuralprogenitorcellsunderlowoxygen..CellReprogram..2011,13(2)::113-20..SCI

8.5.XinHuang,Ling-lingZhua,TongZhao,Li-yingWu,Kui-wuWu,MelittaSchachner,Zhi-ChengXiao,MingFan..CHL1negativelyregulatestheproliferationandneuronaldifferentiationofneuralprogenitorcellsthroughactivationoftheERK1/2MAPKpathway..MolecularandCellularNeuroscience.2011,;46::296–307..SCI

9.7.Jun-XiaZheng,YangZheng,HuiZhi,YiDai,Nai-LiWang,Yan-XiongFang,Zhi-YunDu,KunZhang,Ming-MingLi,Li-YingWu,MingFan..New3′,8′′-LinkedBiflavonoidsfromSelaginellauncinataDisplayingProtectiveEffectagainstAnoxia.Molecules.2011,16,:6206-6214.SCI

10.LiMM,WuLY,ZhaoT,XiongL,HuangX,LiuZH,FanXL,XiaoCR,GaoY,MaYB,ChenJJ,ZhuLL,FanM.Theprotectiveroleof5-HMFagainsthypoxicinjury.CellStressChaperones.2011,16(3)::267-73.SCI

11.3.WuLY,MaZM,FanXL,ZhaoT,LiuZH,HuangX,LiMM,XiongL,ZhangK,ZhuLL,FanM.Theanti-necrosisroleofhypoxicpreconditioningafteracuteanoxiaismediatedbyaldosereductaseandsorbitolpathwayinPC12cells.CellStressChaperones.2010,15(4)::387-94.SCI

12.2.ShiCG,WangLM,WuY,WangP,GanZJ,LinK,JiangLX,XuZQ,FanM..Intranasaladministrationofnervegrowthfactorproducesantidepressant-likeeffectsinanimals.NeurochemRes.2010,35(9)::1302-14.SCI

13.1.ZhaoYQ,GaoJT,LiuSH,WuY,LinMT,FanM.Geranylgeranylacetonepreconditioningmayattenuateheat-inducedinflammationandmultiorgandysfunctioninrats.JPharmPharmacol.2010,62(1)::99-105.SCI

14.5.LiuS,TianZ,YinF,ZhaoQ,FanM.Generationofdopaminergicneuronsfromhumanfetalmesencephalicprogenitorsafterco-culturewithstriatal-conditionedmediaandexposuretoloweredoxygen..BrainResBull..2009,80(1-2)::62-8.SCI

15.CancerInvest.ExpressionandfunctionalrolesofSmad1andBMPR-IBingliomadevelopment.CancerInvest.2009,27(7)::734-40.SCI

16.LeiXiong,TongZhao,XinHuang,Ling-lingZhu*,MingFan*..Heatshockprotein90isinvolvedinregulationofhypoxia-drivenproliferationofembryonicneuralstem/progenitorcells..CellStressandChaperones.2009,14:183-192.SCI

17.kuanzhang,TongZhao,XinHuang,Ling-lingZhu,MingFan..PreinductionofHSP70promoteshypoxictoleranceandfacilitatesacclimatizationtoacutehypobarichypoxiainmousebrain..CellStressandChaperones.2009,【未填寫卷（期）】:【未填寫起止頁碼】.SCI

18.WuHT,FanJ,ZhuLL,FanM.Sema4CExpressioninNeuralStem/ProgenitorCellsandinAdultNeurogenesisInducedbyCerebralIschemia..Jmolneurosci.2009,【未填寫卷（期）】:【未填寫起止頁碼】.SCI

19.ZhangL,ZhengSS,WuHT,WuY,LiuSH,Fan,M,Zhang,J*.IdentificationofBLyS(BLymphocyteStimulator),aNon-Myelin-AssociatedProtein,asaFunctionalLigandforNogo-66Receptor..TheJournalofNeuroscience.2009,29(19):6348–6352.SCI

20.11.JingXT,WuHT,WuY,MaX,LiuSH,WuYR,DingXF,PengXZ,QiangBQ,YuanJG,FanWH,FanM.DIXDC1promotesretinoicacid-inducedneuronaldifferentiationandinhibitsgliogenesisinP19cells.CellMolNeurobiol..2009,29(1)::55-67.SCI

21.10.ZhangK,ZhaoT,HuangX,LiuZH,XiongL,LiMM,WuLY,ZhaoYQ,ZhuLL,FanM.PreinductionofHSP70promoteshypoxictoleranceandfacilitatesacclimatizationtoacutehypobarichypoxiainmousebrain.CellStressChaperones.2009,14(4)::407-15.SCI

22.9.XiongL,ZhaoT,HuangX,LiuZH,ZhaoH,LiMM,WuLY,ShuHB,ZhuLL,FanM.Heatshockprotein90isinvolvedinregulationofhypoxia-drivenproliferationofembryonicneuralstem/progenitorcells..CellStressChaperones.2009,14(2)::183-92.SCI

23.8.WuH,FanJ,ZhuL,LiuS,WuY,ZhaoT,WuY,DingX,FanW,FanM.Sema4Cexpressioninneuralstem/progenitorcellsandinadultneurogenesisinducedbycerebralischemia.JMolNeurosci.2009,39(1-2)::27-39.SCI

24.6.GaoJT,LiuSH,YanYE,WuY,WuHT,XingC,GeXM,WangH,ZhaoYQ,FanM.Quinacrineprotectsneuronalcellsagainstheat-inducedinjury..CellBiolInt.2009,33(8)::874-81.SCI

25.YuS，ZhaoT，F(xiàn)anming.Hypoxicpreconditioningup-regulatesglucosetransportactivityandglucosetransporter(GLUT1andGLUT3)geneexpressionafteracuteanoxicexposureintheculturedrathippocampalneuronsandastrocytes..Brainresearch.2008,23:22-9.SCI

26.WuLY,WangY,FanM.TheroleofhypoxiainthedifferentiationofP19embryonalcarcinomacellsintodopaminergicneurons..NeurochemRes.2008,33:2118-2125.SCI

27.DingX，F(xiàn)anW，F(xiàn)anM.LocalizationandcellulardistributionofCPNE5inembryonicmousebrain..Brainresearch.2008,11:20-8.SCI

28.TangYY,MaYH,FanYX,FengHB,WangJH,FengSG,LuQL,HuB,LinY,LiJ,ZhangY,WangY,ZhouL,FanM*.Centralandautonomicnervoussysteminteractionisalteredbyshort-termmeditation..ProcNatlAcadSciUSA.2008,105:5609-5613.SCI

29.QiangSun1,YanZhang1,GuangYang2,XiaopingChen3,YingaiZhang1,GuojunCao2,.Transforminggrowthfactor-b-regulatedmiR-24promotesskeletalmuscledifferentiation.NucleicAcidsResearchNucleicAcidsResearch.2008,【未填寫卷（期）】:1-10.SCI

30.XuanWang,HaitaoWu,ZhenxingZhang,ShuhongLiu,JianYang,XiaopingChen,MingFan,XiaominWang..EffectsofInterleukin-6,LeukemiaInhibitoryFactor,andCiliaryNeurotrophicFactorontheProliferationandDifferentiationofAdultHumanMyoblasts..CellMolNeurobiol.2008,28:113–124.SCI

31.Yi-YuanTang,YinghuaMa,JunhongWang,YaxinFan,ShigangFeng,QilinLu,QingbaoYu,DanniSui,MaryK.Rothbart,MingFanandMichaelI..PosnerShort-termmeditationtrainingimprovesattentionandself-regulation.PNAS.2008,104:4317152–17156.SCI

32.ZhaoT,Zhangcui-ping,LinglingZhu,FanMing.Hypoxia-drivenproliferationofembryonicneuralstem/progenitorcells--roleofhypoxia-inducibletranscriptionfactor-1alpha..FEBSJ.2008,275(8):1824-34.SCI

33.HaitaoWu,XuanWang,ShuhongLiu,WenhongFan*,MingFan*.Sema4Cparticipatesinthemyogenicdifferentiationinvivoandinvitrothroughp38MAPKpathway..Eur.J.CellBiol..2007,86:331-344.SCI

34.PengZhang,XiaopingChen,MingFan.Signalingmechanismsinvolvedindisusemuscleatrophy.MedHypotheses.2007,69:310–321..SCI

35.【未填作者】.Pathophysiologicalfactorsunderlyingheatstroke.MedHypotheses.2006,22(2):118-123.SCI

36.【未填作者】.Dedifferentiationofadulthumanmyoblastsinducedbyciliaryneurotrophicfactorinvitro..MolBiolCell..2005,16(7):3140-51.SCI

37.【未填作者】.Neurogenesisintheadultratbrainafterintermittenthypoxia..BrainRes..2005,1055(1-2):1-6.SCI

38.LinglingZhu,LiyingWuandMingFan..Effectsofhypoxiaonproliferationanddifferentiationofneuralstemcells.MolNeurobiology.2005,31(1-3):231-242.SCI

39.JingXT,WuHT,FanM.DIXDC1promotesretinoicacid-inducedneuronaldifferentiationandinhibitsgliogenesisinP19cells..cellmolneurobiol.2002,29:55-67.SCI

主編或副主編的著作/譯著

1.《神經(jīng)科學(xué)進展（第三冊）》,主編,高等教育出版社,2004

2.《神經(jīng)科學(xué)進展（第二冊）》,主編,高等教育出版社,2003

3.《特殊環(huán)境生理學(xué)》,副主編,軍事醫(yī)學(xué)出版社,2003

4.《蛋白質(zhì)技術(shù)手冊》,主編,科學(xué)出版社,2000

重要獎項

1.適度低氧促進腦損傷修復(fù)的途徑與應(yīng)用方案軍隊科技進步二等獎201211

2.NGF臨床研究北京市科技進步獎三等2008

3.興奮毒性腦損害干預(yù)研究遼寧省科技進步一等獎2004

4.神經(jīng)營養(yǎng)因子的系列研究北京市科技進步二等獎2003

5.海馬神經(jīng)元缺氧損傷機制及保護措施的研究軍隊科技進步二等獎1999

6.人腦源性神經(jīng)營養(yǎng)因子基因工程及其生物學(xué)作用的研究軍隊科技進步二等獎1998

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