東北農(nóng)業(yè)大學生命科學學院導師:向文勝

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東北農(nóng)業(yè)大學生命科學學院導師:向文勝

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東北農(nóng)業(yè)大學生命科學學院導師:向文勝 正文


  向文勝
  男,1968年生人
  博士,教授,博士生導師,黑龍江省杰出青年基金獲得者,教育部新世紀優(yōu)秀人才,“龍江學者”特聘教授
  聯(lián)系電話:0451-55190413(O)
  傳真電話:0451-55190413
  電子郵箱:

   教育進修
  博士后,浙江大學化學系,2003-2005
  博士后,中國科學院過程工程所,2001-2003
  博士,中國農(nóng)業(yè)大學,1997-2001
  碩士,東北農(nóng)業(yè)大學,1989-1992
  學士,中南民族大學,1985-1989

   工作經(jīng)歷
   2008 - present: Excellent Talents in University, China
   2007 - present: Longjiang Scholar Professor
   2003 - present: Professor,
   2001 - 2003: Associate professor,
   2001 - 2003: Postdoctoral fellow,
   1996 - 2000: Lecturer,
   1993 - 1995: Assistant,

   主講課程
  主講本科生課程《工業(yè)微生物》,主講碩士研究生課程《儀器分析》、《生物化工研究班討論》課程。

   學生培養(yǎng)
  招收培養(yǎng)碩士研究生58名、博士生31名,指導博士后4名。畢業(yè)生中大部分就業(yè)于國內(nèi)知名大學和科研院所,其中13名赴國外深造或工作。1998年被遴選為博士生導師,2000年以來,連續(xù)被評為東北農(nóng)業(yè)大學優(yōu)秀博士生導師,省第三屆和第四屆優(yōu)秀研究生學位論文指導教師,黑龍江省研究生優(yōu)秀導師等。

   研究方向
   Current research interests are about isolating and screening of antibiotic-generating strain, secondary metabolite biosynthesis in microorganisms, gene cloning and expression, enzyme reaction mechanisms, metabolic pathway engineering, and natural product drug discovery and development.

   研究課題
   (1) 國家科技支撐計劃重點項目——新型抗寄生蟲原料藥的研制與應(yīng)用,2007-2010
   (2 ) 國家科技支撐計劃重點項目子項目——抗寄生蟲類藥物篩選新技術(shù),2007-2010
   (3) 教育部新世紀優(yōu)秀人才計劃——農(nóng)用抗生素米爾貝霉素的生物合成與調(diào)控,2009-2011
   (4) 國家自然基金——高選擇性谷氨酸門控氯離子通道篩選體系研究與應(yīng)用,2008-2010
   (5) 國家自然科學基金——γ-氨基丁酸受體親和篩選模型的構(gòu)建和獲得新配體方法的建立及應(yīng)用,2006-2008
   (6) 國家自然科學基金——基于與天門冬酰胺合成酶結(jié)合小分子信號的混合篩選及先導化合物的發(fā)現(xiàn),2005-2005
   (7) 國家自然科學基金——P450體外代謝除草劑模型的構(gòu)建及作用,2003-2005
   (8) 國家自然科學基金——P450催化除草劑代謝速率及羥基化位點與化合物結(jié)構(gòu)的關(guān)系,2000-2002
   (9) 國家自然科學基金——抗草甘膦EPSP合酶基因克隆及抗性機理,1997-1999
   (10) 黑龍江省杰出青年基金,冰城鏈霉菌生物合成米爾貝霉素基因簇及調(diào)控基因克隆與高產(chǎn)代謝工程菌的構(gòu)建,2008-2010
   (11) “973”子項目,農(nóng)藥活性化合物及菌株篩選,2004-2008
   (12) “龍江學者特聘教授”配套基金項目,2008-2010
   (13) 省重點項目,多拉菌素工程菌的構(gòu)建,2008-2010
   (14) 哈爾濱市科委重點項目,多拉菌素高產(chǎn)優(yōu)良的選育,2007-2009
   (15) “973”子項目,農(nóng)藥活性化合物篩選及與靶分子的作用,2010-2014

   獲獎成果
  黑龍江省科技進步二等獎2項
  黑龍江省科技進步三等獎1項
  黑龍江省青年獎1項
  大北農(nóng)科技獎1項
  獲得國家發(fā)明專利4項

   論文著作
  發(fā)表論文
   1. Xiang-Jing Wang, Ming Wang, Ji-Dong Wang, Wen-Sheng Xiang. Isolation and Identification of Novel Macrocyclic Lactones from Streptomyces Avermitilis NEAU1069 with Acaricidal and Nematocidal Activity, Journal of Agricultural and Food Chemistry, (publishing)
   2. Ming Wang, Xiao-Hu Yang, Ji-Dong Wang, Xiang-Jing Wang, Zheng-Jie Chen, Wen-Sheng Xiang. New β-Class Milbemycin Compound from Streptomyces avermitilis NEAU1069: Fermentation, Isolation and Structure Elucidation, J. Antibiotics, 2009, 62(10):587-591
   3. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Ji Zhang, Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties, J. Antibiotics, 2009, 62(9):501-505
   4. Lu Shi-Xiang, Guo Yang-Hui, Wang Ya-Ping, Wang Xiang-Jing, Xiang Wen-Sheng. A novel synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester, Chinese Journal of Organic Chemistry, 2009,
   5. Xiang-Jing Wang, Suo-Lian Guo, Wan-Qian Guo, Wen-Sheng Xiang. Role of nsdA in Negative Regulation of Antibiotic Production and Morphological Differentiation in Streptomyces bingchengensis, J. Antibiotics, 2009, 62(6):329-13
   6. Xiang-Jing Wang, Xiao-Chong Wang, Wen-Sheng Xiang. Improvement of milbemycin-producing Streptomyces bingchenggensis by rational screening of ultraviolet- and chemically induced mutants, World Journal of Microbiology and Biotechnology, 2009, 25:1051-1056
   7. Xiang-Jing Wang, Ji-Dong Wang, Wen-Sheng Xiang. Three new milbemycin derivatives from Streptomyces bingchenggensis, Journal of Asian Natural Products Research, 2009, 11 (7), 597-603
   8. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, A novel macrolide compound from the Streptomyces bingchenggensis, Fermentation, Isolation, Structure Elucidation and Biological Properties, J. Antibiotics, 2009, 62(4):229-31
   9. Hai Bo Sun, Guo Jun Zheng , Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan, Chinese Chemical Letters, 20 (2009) 269-270
   10. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Optimization of culture conditions for hydrogen production by Ethanoligenens harbinense B49 using response surface methodology. Bioresource Technology, 2009, 100 (3): 1192-6
   11. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, New Seco-milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation and Structure Elucidation, J.Antibiotics, 2008, 61 (1): 27-32
   12. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, Two new components from Gnetum pendulum, J. of Asian Natural Products Research, 2008, 10: 1-5
   13. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Biohydrogen production from ethanol-type fermentation of molasses in an expanded granular sludge bed (EGSB) reactor. Int J Hydrogen Energy, 2008, 33(19): 4981~4988
   14. Wan-Qian Guo, Nan-Qi Ren, Xiang-Jing Wang, Wen-Sheng Xiang. Simultaneous biohydrogen production and starch wastewater treatment in an acidogenic expanded granular sludge bed reactor by mixed culture for long-term operation. Int J Hydrogen Energy, 2008, 33: 7397-7404
   15. Nan-Qi Ren, Wan-Qian Guo, Xiang-Jing Wang, Wen-Sheng Xiang. Effects of different pretreatment methods on fermentation types and dominant bacteria for hydrogen production. Int J Hydrogen Energy, 2008, 33 (16): 4318~4324
   16. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang. Two new milbemycins from Streptomyces bingchenggensis Fermentation, Isolation, Structure Elucidation and Biological properties, J. Antibiotics, 2007, 60 (6):351-356
   17. iangjing Wang, Nanqi Ren, Wensheng Xiang. Influence of Gaseous End-products Inhibition and Nutrient Limitations on the Growth and Hydrogen Production by Hydrogen-producing Fermentative Bacterial B49, International Journal of hydrogen Energy, 2007(32):748-754
   18. Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang. Further New Milbemycin Antibiotics from Streptomyces bingchenggensis, J .Antibiotics, 2007, 60 (10): 608-613
   19. Wensheng Xiang, Xiangjing Wang, Expression of a wheat cytochrome P450 monooxygenase cDNA in yeast catalyzes the metabolism of sulfonylurea herbicide. Pest. Biochem. Physio, 2006, 85(1):1-6
   20. Xiang Wensheng, Wang Xiangjing, Purification of recombinant wheat cytochrome P450 monooxygenase expressed in yeast and its properties, Protein Expression and Purification, 2006(1):54-59
   21. Wensheng Xiang, Xiangjing Wang, Expression of a wheat cytochrome P450 monooxygenase cDNA in yeast catalyzes the metabolism of sulfonylurea herbicide. Pest. Biochem. Physio, 2006, 85(1):1~6
  著作、教材
   (1) “十一五”規(guī)劃教材《儀器分析》,主編,哈爾濱工業(yè)大學出版社
   (2) 《現(xiàn)代農(nóng)業(yè)儀器分析應(yīng)用技術(shù)》主編,東北林業(yè)大學出版社
   (3) 《生物化學過程工程學》 副主編,科學出版社
 

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