蘭州大學(xué)研究生導(dǎo)師：張勝祥 正文

　　學(xué)習(xí)經(jīng)歷

　　2007-2009    美國(guó)紐約大學(xué), Skirball生物分子醫(yī)學(xué)研究所，博士后

　　Postdoctoral training, New York University, 2007-2009

　　2001-2007    加拿大不列顛哥倫比亞大學(xué)，腦研究中心，博士

　　Ph. D., The University of British Columbia, 2007

　　1995-1998    蘭州大學(xué)，生物系，碩士

　　M.S., Department of Biology, Lanzhou University, 1998

　　1991-1995    蘭州大學(xué)，生物系，學(xué)士

　　B.S., Department of Biology, Lanzhou University, 1995

　　工作經(jīng)歷

　　2009-現(xiàn)在     蘭州大學(xué)，生命科學(xué)學(xué)院，動(dòng)物學(xué)與發(fā)育生物學(xué)研究所，萃英特聘教授

　　School of Life Sciences, Lanzhou University

　　2007-2009    美國(guó)紐約大學(xué), Skirball生物分子醫(yī)學(xué)研究所，博士后

　　Skirball Institute of Biomolecular Medicine, New York University

　　1998-2000    南京大學(xué)，生物系，助教

　　Department of Biology, Nanjing University

　　教學(xué)及指導(dǎo)研究生情況

　　指導(dǎo)研究生：

　　碩士研究生招生方向：發(fā)育神經(jīng)生物學(xué)；

　　博士研究生招生方向：發(fā)育神經(jīng)生物學(xué)、動(dòng)物生理學(xué)。

　　注：碩士研究生招生專業(yè)為發(fā)育生物學(xué)(071008)

　　教學(xué)：

　　主講本科生課程：發(fā)育生物學(xué)；

　　主講研究生課程：發(fā)育生物學(xué)研究方法，動(dòng)物生理學(xué)專題等。

　　發(fā)表論文及專著

　　Publications：

　　Zhu, L., Wang, L., Ju, F., Khan, A., Cheng, X. & Zhang, S. (2017) Reversible recovery of neuronal structures depends on the degree of neuronal damage after global cerebral ischemia in mice. Experimental Neurology 289:1-8.

　　Khan, A., Ju, F., Xie, W., Tariq Hafeez, M., Cheng, X., Yang, Z., Zhu, L., Li, T. & Zhang, S. (2017) Transcriptomic analysis reveals differential activation of microglial genes after ischemic stroke in mice. Neuroscience 348:212-227.

　　Zhu, L., Wang, L., Ju, F., Ran, Y., Wang, C. & Zhang, S. (2016) Transient global cerebral ischemia induces rapid and sustained reorganization of synaptic structures. Journal of Cerebral Blood Flow and Metabolism.

　　Wang, C., Tao, S., Fang, Y., Guo, J., Zhu, L. & Zhang, S. (2016) Infiltrating cells from host brain restore the microglial population in grafted cortical tissue. Scientific Reports 6:33080.

　　Li, L., Du, Y., Ju, F., Ma, S. & Zhang, S. (2016) Calcium plays a key role in paraoxon-induced apoptosis in EL4 cells by regulating both endoplasmic reticulum- and mitochondria-associated pathways. Toxicology Mechanisms and Methods 26(3):211-20.

　　Li, T. & Zhang, S. (2016) Microgliosis in the Injured Brain: Infiltrating Cells and Reactive Microglia Both Play a Role. The Neuroscientist 22(2):165-70.

　　Li, D., Guo, J., Zhou, X., Chang, C. & Zhang, S. (2016) The complete mitochondrial genome of Phrynocephalus helioscopus (Reptilia, Squamata, Agamidae). Mitochondrial DNA A DNA Mapp Seq Anal 27(3):1846-7.

　　Sun, C.-L., Liao, Q., Li, T., Li, J., Jiang, J.-Q., Xu, Z.-Z., Wang, X.-D., Shen, R., Bai, D.-C., Wang, Q., Zhang, S.-X., Fu, H.-B. & Zhang, H.-L. (2015) Rational design of small indolic squaraine dyes with large two-photon absorption cross section. Chemical Science 6(1):761-769.

　　Tang, P., Zhang, Y., Chen, C., Ji, X., Ju, F., Liu, X., Gan, W.B., He, Z., Zhang, S., Li, W. & Zhang, L. (2015) In vivo two-photon imaging of axonal dieback, blood flow, and calcium influx with methylprednisolone therapy after spinal cord injury. Scientific Reports 5:9691.

　　Wang, Y., Wang, Q., Lv, S. & Zhang, S. (2015) Different protein of Echinococcus granulosus stimulates dendritic induced immune response. Parasitology 142(7):879-89.

　　Zhang, Y., Zhang, L., Ji, X., Pang, M., Ju, F., Zhang, J., Li, W., Zhang, S., He, Z., Gan, W.B. & Tang, P. (2015) Two-photon microscopy as a tool to investigate the therapeutic time window of methylprednisolone in a mouse spinal cord injury model. Restorative Neurology and Neuroscience 33(3):291-300.

　　Liu, C.J., Du, B., Liu, N.F., Bao, S.J. & Zhang, S. (2014) Sex-specific parental care strategies via nestling age: females pay more attention to nestling demands than males do in the horned lark, Eremophila alpestris. Zoological Science 31(6):348-52.

　　Li, T., Pang, S., Yu, Y., Wu, X., Guo, J. & Zhang, S. (2013) Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke. Brain 136(Pt 12):3578-88.

　　Wang, J., Feng, X., Du, Y., Wang, L. & Zhang, S. (2013) Combination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice. Restorative Neurology and Neuroscience 31(4):487-99.

　　Lu, B., Li, T., Zhao, H., Li, X., Gao, C., Zhang, S. & Xie, E. (2012) Graphene-based composite materials beneficial to wound healing. Nanoscale 4(9):2978-82.

　　Zhang, S., Wang, J. & Wang, L. (2010) Structural plasticity of dendritic spines. Frontiers in Biology 5(1):48-58.

　　Bhatt, D.H., Zhang, S. & Gan, W.B. (2009) Dendritic spine dynamics. Annual Review of Physiology 71:261-82.

　　Enright, L.E., Zhang, S. & Murphy, T.H. (2007) Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo. Journal of Cerebral Blood Flow and Metabolism 27(6):1185-200.

　　Zhang, S. & Murphy, T.H. (2007) Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo. PLoS Biology 5(5):e119.

　　Zhang, S., Boyd, J., Delaney, K. & Murphy, T.H. (2005) Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. Journal of Neuroscience 25(22):5333-8.

　　Zhang, S. & Murphy, T.H. (2004) Ca(2+)-independent spine dynamics in cultured hippocampal neurons. Molecular and Cellular Neurosciences 25(2):334-44.

　　研究方向

　　1 、腦中風(fēng)后突觸結(jié)構(gòu)可塑性的細(xì)胞和分子機(jī)理。突觸是神經(jīng)元之間的連接點(diǎn)，是學(xué)習(xí)和記憶的結(jié)構(gòu)基礎(chǔ)。課題組主要研究方向之一是探討腦中風(fēng)后影響突觸結(jié)構(gòu)可塑性的細(xì)胞和分子機(jī)理。我們利用轉(zhuǎn)基因熒光小鼠，活體內(nèi)雙光子熒光顯微成像和內(nèi)源性光學(xué)信號(hào)成像等技術(shù)，以及細(xì)胞生物學(xué)、分子生物學(xué)和行為學(xué)等研究方法，嘗試揭示病理?xiàng)l件下神經(jīng)環(huán)路的改變與大腦功能恢復(fù)之間的關(guān)系。

　　2、 小膠質(zhì)細(xì)胞激活和增殖的調(diào)控機(jī)制。小膠質(zhì)細(xì)胞是中樞神經(jīng)系統(tǒng)內(nèi)具有免疫功能的細(xì)胞。在正常腦組織中，小膠質(zhì)細(xì)胞處于靜息態(tài)，對(duì)周圍的組織起著監(jiān)測(cè)和保護(hù)作用。在病理情況下，小膠質(zhì)細(xì)胞被迅速激活，并在損傷區(qū)周圍增生。課題組目前的興趣主要是利用多種轉(zhuǎn)基因工具鼠，結(jié)合活體成像和細(xì)胞培養(yǎng)等手段探討腦中風(fēng)后小膠質(zhì)細(xì)胞增生的功能及調(diào)控機(jī)制。

　　項(xiàng)目成果

　　主持基金項(xiàng)目:

　　以項(xiàng)目負(fù)責(zé)人身份主持國(guó)家自然科學(xué)基金面上項(xiàng)目3項(xiàng)， 甘肅省科技計(jì)劃項(xiàng)目-科技支撐計(jì)劃1項(xiàng)，高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金-博導(dǎo)類項(xiàng)目1項(xiàng)；

　　榮譽(yù)、獲獎(jiǎng)

　　社會(huì)工作

　　甘肅省動(dòng)物學(xué)會(huì)副理事長(zhǎng)

 

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