中國藥科大學基礎(chǔ)部導師：陳亞東 正文

　　個人簡介
　　陳亞東，男，1970年5月生。博士，副教授，碩士研究生導師。
　　1995年碩士畢業(yè)于吉林大學化學系，后入中國藥科大學工作，2009年獲中國藥科大學藥物化學博士學位。目前主要從事基于重大疾病相關(guān)性分子靶標的新藥發(fā)現(xiàn)，以及藥物設(shè)計新方法的研究。主持和參與了國家重大科技專項“重大新藥創(chuàng)制”（No.2009ZX09501-03）、國家自然科學基（No. 30772624 ；No.30973609）,江蘇省自然科學基金（No.BK2006151）等多項科研項目。2008年獲江蘇省“青藍工程”青年骨干教師稱號。主編或參編學術(shù)著作和教材3本；申請國內(nèi)專利7項，已授權(quán)2項；已在J. Chem. Inf. Model. ,Eur. J. Med. Chem.、J. Mol. Graph. Model等國際SCI學術(shù)期刊發(fā)表論文近30篇。多次受邀擔當Eur. J. Med. Chem.、J. Mol. Model.等國際SCI期刊審稿專家。
　　 
　　主要研究方向
　　1）基于重要靶標的藥物設(shè)計研究
　　結(jié)合理性的藥物設(shè)計、化學合成及生物學評價，開展針對重大疾病（如腫瘤、心血管、糖尿病等）的藥物設(shè)計研究，力爭發(fā)現(xiàn)具有較好活性的先導化合物。
　　2) 計算機輔助藥物設(shè)計新方法研究
　　應用化學、生物學和計算科學等交叉學科的新方法和新技術(shù)，發(fā)展新的藥物設(shè)計方法和技術(shù)。如基于靶標結(jié)構(gòu)的高通量虛擬篩選方法、基于天然活性成分的反向靶標虛擬篩選方法、基于靶標三維結(jié)構(gòu)的集中組合庫設(shè)計和基于分子碎片的全新藥物設(shè)計方法等。
　　 
　　近年代表性論文
　　[1] Haoliang Yuan, Tao Lu, Ting Ran, Haichun Liu, Shuai Lu, Wenting Tai, Ying Leng, Weiwei Zhang, Jian Wang and Ya-Dong Chen*, A novel lead identification strategy based on three-dimensional fragment approaches. J. Chem. Inf. Model., 2011，51(4),959-974
　　[2] Ting Ran, Tao Lu, Haoliang Yuan, Haichun Liu, Jian Wang, Weiwei Zhang, Ying Leng, Ya-Dong Chen*, A selectivity study on mTOR/PI3Kα inhibitors by homology modeling and 3D-QSAR, J. Mol. Model. 2011 Apr 27 DOI: 10.1007/s00894-011-1034-3
　　[3] Yayu Tan, Yadong Chen*, Qidong You, Haopeng Sun and Manhua Li. Predicting the potency of hERG K+ channel inhibition by combining 3D-QSAR pharmacophore and 2D-QSAR models. J. Mol. Model. 2011 Jun 10 DOI: 10.1007/s00894-011-1136-y
　　[4] Xiu-Mei Chen, Tao Lu, Shuai Lu, Hui-Fang Li, Hao-Liang Yuan, Ting Ran, Hai-Chun Liu, Ya-Dong Chen*. Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors. J. Mol. Model. 2010, 16:1195–1204.
　　[5] Yadong Chen, Huifang Li, Wanquan Tang, Chengchao Zhu, Yongjun Jiang, Jianwei Zou,Qingsen Yu, Qidong You. 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur. J. Med. Chem.(2009), 44:2868-2876
　　[6] Hui-Fang Li, Tao Lu, Tian Zhu, Yong-Jun Jiang, Sha-Sha Rao, Li-Ye Hu, Bo-Tao Xin and Ya-Dong Chen*. Virtual screening for Raf-1 kinase inhibitors based on pharmacophore model of substituted ureas. Eur. J. Med. Chem.(2008), 44(3):1240-1249
　　[7]Ya-Dong Chen, Yong-Jun Jiang, Jian-Wei Zhou, Qing-Sen Yu and Qi-Dong You. Identification of Ligand Features Essential for HDACs Inhibitors by Pharmacophore Modeling. J. Mol. Graph. Model., 2008,26 ,1160–1168
　　[8] Xiang Zhou, Ya-Dong Chen, Tao Wang, Xiao-Bing Wang, Ling-Yi Kong. Rational design, synthesis, biological evaluation, homology and docking studies of coumarin derivatives as α1 -adrenoceptor antagonists. Chem. Biodivers. 2011 Jun; 8(6):1052-64.
　　[9] Xiao-Yun Lu, Ya-Dong Chen, Qi-Dong You. 3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors. J. Enzyme. Inhib. Med. Chem. 2010 Apr;25(2):240-9.
　　[10] Huifang Li, Yadong Chen, Shasha Rao, Jihong Qin, Haichun Liu, Weifang Tang, Yue Wang, Xiang Zhou, Tao Lu. Recent Advances in the Research and Development of B-Raf. Curr. Med. Chem. 2010, 17, 1618-1634
　　[11] Xiao-Yun Lu, Ya-Dong Chen, Qi-Dong You. 3D-QSAR studies of arylcarboxamides with inhibitory activity on InhA using pharmacophore-based alignment. Chem. Biol. Drug. Des. 2010;75(2):195-203
　　[12] Xiao-Yun Lu, Ya-Dong Chen, Ni-yue Sun, Yong-Jun Jiang, Qi-Dong You Molecular-docking-guided 3D-QSAR studies of substituted isoquinoline-1,3-(2H,4H)-diones as cyclin-dependent kinase 4 (CDK4) inhibitors. J. Mol. Model. 2010;16(2):163-73.
　　[13] Hong Su, Liqin Yu, Angela Nebbioso, Vincenzo CaRafa, Yadong Chen, Lucia Altucci, Qidong You. Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group. Bioorg. Med. Chem. Lett. 2009 ,19(22):6284-8
　　[14] Xiao-Yun Lu, Ya-Dong Chen, Yong-Jun Jiang, Qi-Dong You. Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur. J. Med. Chem.(2009)44:3718-3730
　　[15] Ji Zhang, Tao Lu, Chen Jiang, Jianwei Zou, Fengqi Cao, Yadong Chen. Mechanisms for chemical transformations of (R,R)-tartaric acid on Cu(110):A first principles study. Journal of Chemical Physics. 2009;131(14):144703.
　　[16] Tian Zhu, Yu Jiao, Ya-Dong Chen, Xuan Wang, Hui-Fang Li, Lu-Yong Zhang, Tao Lu. Pharmacophore identification of the Raf-1 kinase inhibitors. Bioorg. Med. Chem. Lett. 2008,18(7):2346-50.
　　[17] Hong Su, Angela Nebbioso, Vincenzo CaRafa, Yadong Chen, Bo Yang, Lucia Altucci, Qidong You. Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents. Bioorg. Med. Chem. 2008, 16 ,7992–8002
　　[18] Fei Liu, Qi-Dong You and Ya-Dong Chen. Pharmacophore identification of KSP inhibitors. Bioorg. Med Chem. Lett., 2007, 17(3), 722-726
　　[19] Cheng Jiang , Yadong Chen , Xiaojian Wang, Qi-dong You. Docking studies on kinesin spindle protein inhibitors:an important cooperative "minor binding pocket" which increases the binding affinity significantly. J. Mol. Model ,2007,13:987–992
　　[20] Shu-Lin Zhuang, Qing-Sen Yu, Jian-Wei Zou, Yong-Jun Jiang, Ya-Dong Chen, Hua-Xing Zhang, Hai-Xiao Jin, Hai-Chun Liu and Na Zhang. A study of the interaction of cinnamate analogues with macrophage migration inhibitory factor (MIF) and P1G mutant from molecular dynamics simulations. J. Mol. Struct.: THEOCHEM, 2006, 763(1-3), 97-101.
　　 
　　招生對象
　　課題組歡迎有藥學、中藥學、化學、生物學、計算機背景的學生前來報考和加盟。
　　 
　　聯(lián)系方式
　　Tel: 025-86185163 E-mail:
　

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